MeSH

An adenine arabinonucleoside derivative that acts as an antineoplastic antimetabolite. It is used in the treatment of ACUTE LYMPHOID LEUKEMIA in pediatric patients who have relapsed.

Year introduced: 2019 (1991)

Antimetabolites that are useful in cancer chemotherapy.

Year introduced: 1975

Nucleotides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)

Year introduced: 1973(1971)

A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.

Purines attached to a RIBOSE and a phosphate that can polymerize to form DNA and RNA.

Year introduced: 1974(1972)

The monomeric units from which DNA or RNA polymers are constructed. They consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group. (From King and Stansfield, A Dictionary of Genetics, 4th ed)

Complex compounds of high molecular weight occurring in living cells. These are basically of two types, ribonucleic (RNA) and deoxyribonucleic (DNA) acids, both of which consist of nucleotides (nucleoside phosphates linked together by phosphate bridges).

Year introduced: 1998

Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King and Stansfield, A Dictionary of Genetics, 4th ed)

A class of heterocyclic compounds that include a two-ring fused structure. Both aromatic and non-aromatic ring structures are included in this category.

Year introduced: 1998

Cyclic compounds that include atoms other than carbon in their ring structure.

Nucleosides containing arabinose as their sugar moiety.

Year introduced: 1979

Multiple ring heterocyclic compounds containing two or more rings that share two atoms and one bond in common.

Year introduced: 2017

Uses of chemicals which affect the course of conditions, diseases, syndromes or pathology to benefit the health of an individual.

Year introduced: 2004

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.

Year introduced: 2008(2004)

A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.

Year introduced: 2004(1999)

A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.

Year introduced: 1999

Agents capable of exerting a harmful effect on the body.

Year introduced: 1998

A broad category of chemical actions with harmful or deadly effect on living organisms.

Year introduced: 2004(1998)

Substances that inhibit or prevent the proliferation of NEOPLASMS.