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Items: 19

1.

2-((3-acrylamido-4-methylphenyl)amino)-N-(2-methyl-5-(3,4,5-trimethoxybenzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide [Supplementary Concept]

type II irreversible bone marrow kinase in the X chromosome (BMX) kinase inhibitor; structure in first source

Date introduced: August 3, 2017

2.

Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES.

Year introduced: 2005

3.

Pyrimidines

A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.

Year introduced: THONZYLAMINE was heading 1972-1984 (Prov 1972)

4.

Organic Chemicals

A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.

Year introduced: 1998

5.

Hydrocarbons, Cyclic

Organic compounds composed exclusively of carbon and hydrogen forming a closed ring that may be either alicyclic or aromatic.

Year introduced: 1998

6.

Hydrocarbons, Aromatic

Organic compounds containing carbon and hydrogen in the form of an unsaturated, usually hexagonal ring structure. The compounds can be single ring, or double, triple, or multiple fused rings.

Year introduced: 1998

7.

Hydrocarbons

Organic compounds that primarily contain carbon and hydrogen atoms with the carbon atoms forming a linear or circular structure.

8.

Heterocyclic Compounds, 1-Ring

Organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.

Year introduced: 1998

9.

Heterocyclic Compounds

Cyclic compounds that include atoms other than carbon in their ring structure.

10.

Carboxylic Acids

Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.

Year introduced: 1973(1971)

11.

Benzoates

Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.

Year introduced: 1963

12.

Benzene Derivatives

Organic compounds derived from BENZENE.

Year introduced: 1968

13.

Benzamides

BENZOIC ACID amides.

Year introduced: 1973

14.

Amides

Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant and Hackh's Chemical Dictionary, 5th ed)

15.

Acids, Carbocyclic

Carboxylic acids that have a homocyclic ring structure in which all the ring atoms are carbon.

Year introduced: 1998

16.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.

Year introduced: 2008(2004)

17.

Pharmacologic Actions

A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.

Year introduced: 2004(1999)

18.

Chemical Actions and Uses

A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.

Year introduced: 1999

19.

Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Year introduced: 1975(1964)

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