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An indole and pyrrole derivative that inhibits VEGFR-2 and PDGFR BETA RECEPTOR TYROSINE KINASES. It is used as an antineoplastic agent for the treatment of GASTROINTESTINAL STROMAL TUMORS, and for treatment of advanced or metastatic RENAL CELL CARCINOMA.

Year introduced: 2019 (2003)


Protein Kinase Inhibitors

Agents that inhibit PROTEIN KINASES.

Year introduced: 2005


Angiogenesis Inhibitors

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

Year introduced: 2004(2000)


Antineoplastic Agents

Substances that inhibit or prevent the proliferation of NEOPLASMS.



Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.



Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.


Heterocyclic Compounds, 2-Ring

A class of heterocyclic compounds that include a two-ring fused structure. Both aromatic and non-aromatic ring structures are included in this category.

Year introduced: 1998


Heterocyclic Compounds, 1-Ring

Organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.

Year introduced: 1998


Heterocyclic Compounds

Cyclic compounds that include atoms other than carbon in their ring structure.



Five membered rings containing a NITROGEN atom.


Heterocyclic Compounds, Fused-Ring

Multiple ring heterocyclic compounds containing two or more rings that share two atoms and one bond in common.

Year introduced: 2017


Therapeutic Uses

Uses of chemicals which affect the course of conditions, diseases, syndromes or pathology to benefit the health of an individual.

Year introduced: 2004


Physiological Effects of Drugs

Activities which affect organs and systemic functions without regard to a particular disease.

Year introduced: 2004


Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY.

Year introduced: 2008(2004)


Angiogenesis Modulating Agents

Agents that modulate the PHYSIOLOGIC ANGIOGENESIS process. This is accomplished by endogenous ANGIOGENIC PROTEINS and a variety of other chemicals and pharmaceutical agents.

Year introduced: 2004


Pharmacologic Actions

A broad category of chemical actions and uses that result in the prevention, treatment, cure or diagnosis of disease. Included here are drugs and chemicals that act by altering normal body functions, such as the REPRODUCTIVE CONTROL AGENTS and ANESTHETICS. Effects of chemicals on the environment are also included.

Year introduced: 2004(1999)


Chemical Actions and Uses

A group of pharmacologic activities, effects on living systems and the environment, and modes of employment of drugs and chemicals. They are broken into actions, which describe their effects, and uses, which describe how they are employed.

Year introduced: 1999


Growth Substances

Signal molecules that are involved in the control of cell growth and differentiation.


Growth Inhibitors

Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).

Year introduced: 1979


Enzyme Inhibitors

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.

Year introduced: 1975,1964-1967

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