* 300227

SCM POLYCOMB GROUP PROTEIN-LIKE 1; SCML1


Alternative titles; symbols

SEX COMB ON MIDLEG, DROSOPHILA, HOMOLOG-LIKE 1


HGNC Approved Gene Symbol: SCML1

Cytogenetic location: Xp22.13     Genomic coordinates (GRCh38): X:17,737,128-17,754,985 (from NCBI)


TEXT

Cloning and Expression

Using exon trapping on a contig from Xp22, van de Vosse et al. (1998) identified a novel human gene with significant sequence similarity to the Drosophila Scm ('sex comb on midleg') gene, a member of the Drosophila Polycomb group (PcG) of genes that are involved in the regulation of homeotic genes. They therefore named the gene SCM-like-1 (SCML1). Northern blot analysis detected a major approximately 3-kb SCML1 transcript in all human adult and fetal tissues tested, with the highest expression in adult skeletal muscle and heart and fetal liver. The predicted 208-amino acid SCML1 protein contains 2 domains that are present in PcG gene products and their mammalian homologs. The SCML1 protein also shares high sequence similarity with the Drosophila polyhomeotic (Ph) gene product, mouse Mph1, and human EDR1 (602978) and EDR2 (602979), all of which are PcG members or homologs. The authors identified cDNAs representing alternatively spliced SCML1 transcripts.


Gene Structure

The SCML1 gene spans 18 kb and contains 6 exons. It is transcribed from telomere to centromere.


Mapping

Van de Vosse et al. (1998) found that the SCML1 gene is located 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, in Xp22.2-p22.1.


REFERENCES

  1. van de Vosse, E., Walpole, S. M., Nicolaou, A., van der Bent, P., Cahn, A., Vaudin, M., Ross, M. T., Durham, J., Pavitt, R., Wilkinson, J., Grafham, D., Bergen, A. A. B., van Ommen, G.-J. B., Yates, J. R. W., den Dunnen, J. T., Trump, D. Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. Genomics 49: 96-102, 1998. [PubMed: 9570953, related citations] [Full Text]


Creation Date:
Patti M. Sherman : 1/24/2000
carol : 02/05/2020
carol : 01/27/2014
mgross : 1/27/2000
mgross : 1/24/2000
psherman : 1/24/2000
psherman : 1/24/2000

* 300227

SCM POLYCOMB GROUP PROTEIN-LIKE 1; SCML1


Alternative titles; symbols

SEX COMB ON MIDLEG, DROSOPHILA, HOMOLOG-LIKE 1


HGNC Approved Gene Symbol: SCML1

Cytogenetic location: Xp22.13     Genomic coordinates (GRCh38): X:17,737,128-17,754,985 (from NCBI)


TEXT

Cloning and Expression

Using exon trapping on a contig from Xp22, van de Vosse et al. (1998) identified a novel human gene with significant sequence similarity to the Drosophila Scm ('sex comb on midleg') gene, a member of the Drosophila Polycomb group (PcG) of genes that are involved in the regulation of homeotic genes. They therefore named the gene SCM-like-1 (SCML1). Northern blot analysis detected a major approximately 3-kb SCML1 transcript in all human adult and fetal tissues tested, with the highest expression in adult skeletal muscle and heart and fetal liver. The predicted 208-amino acid SCML1 protein contains 2 domains that are present in PcG gene products and their mammalian homologs. The SCML1 protein also shares high sequence similarity with the Drosophila polyhomeotic (Ph) gene product, mouse Mph1, and human EDR1 (602978) and EDR2 (602979), all of which are PcG members or homologs. The authors identified cDNAs representing alternatively spliced SCML1 transcripts.


Gene Structure

The SCML1 gene spans 18 kb and contains 6 exons. It is transcribed from telomere to centromere.


Mapping

Van de Vosse et al. (1998) found that the SCML1 gene is located 14 kb centromeric of marker DXS418, between DXS418 and DXS7994, in Xp22.2-p22.1.


REFERENCES

  1. van de Vosse, E., Walpole, S. M., Nicolaou, A., van der Bent, P., Cahn, A., Vaudin, M., Ross, M. T., Durham, J., Pavitt, R., Wilkinson, J., Grafham, D., Bergen, A. A. B., van Ommen, G.-J. B., Yates, J. R. W., den Dunnen, J. T., Trump, D. Characterization of SCML1, a new gene in Xp22, with homology to developmental polycomb genes. Genomics 49: 96-102, 1998. [PubMed: 9570953] [Full Text: https://doi.org/10.1006/geno.1998.5224]


Creation Date:
Patti M. Sherman : 1/24/2000

Edit History:
carol : 02/05/2020
carol : 01/27/2014
mgross : 1/27/2000
mgross : 1/24/2000
psherman : 1/24/2000
psherman : 1/24/2000