Alternative titles; symbols
HGNC Approved Gene Symbol: UTP14A
Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,906,164-129,929,752 (from NCBI)
Using SEREX (serologic analysis of recombinant cDNA expression libraries), Scanlan et al. (1998) cloned UTP14A, which they called NY-CO-16, from a colon cancer cDNA library. The deduced 286-amino acid protein has a nuclear targeting signal.
Rohozinski and Bishop (2004) identified mouse and human UTP14A and UTP14B (UTP14C; 608969). The deduced UTP14A protein shares 77% amino acid identity with mouse Utp14a and 90% identity with human UTP14B. RT-PCR showed that the mouse Utp14a gene was ubiquitously expressed, and the authors found that human UTP14A was also ubiquitously expressed.
Rohozinski and Bishop (2004) determined that the UTP14A gene contains 14 coding exons. The mouse Utp14a gene contains 15 coding exons.
By genomic sequence analysis, Rohozinski and Bishop (2004) mapped the UTP14A gene to the X chromosome. They also mapped the mouse Utp14a gene to the X chromosome.
Rohozinski, J., Bishop, C. E. The mouse juvenile spermatogonial depletion (jsd) phenotype is due to a mutation in the X-derived retrogene, mUtp14b. Proc. Nat. Acad. Sci. 101: 11695-11700, 2004. [PubMed: 15289605] [Full Text: https://doi.org/10.1073/pnas.0401130101]
Scanlan, M. J., Chen, Y.-T., Williamson, B., Gure, A. O., Stockert, E., Gordan, J. D., Tureci, O., Sahin, U., Pfreundschuh, M., Old, L. J. Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer 76: 652-658, 1998. [PubMed: 9610721] [Full Text: https://doi.org/10.1002/(sici)1097-0215(19980529)76:5<652::aid-ijc7>3.0.co;2-p]