Alternative titles; symbols
HGNC Approved Gene Symbol: CT47A11
Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,933,840-120,937,158 (from NCBI)
Chen et al. (2006) identified LOC255313, which encodes a 288-amino acid protein, as 1 of 13 copies of the CT47 gene on chromosome Xq24. The copies are numbered from the most telomeric copy CT47.1 (CT47A1; 300780) through the most centromeric copy CT47.13 (CT47B1; 300790). Of the 13 CT47 copies, 11 are exact or nearly exact, sharing more than 99% nucleotide identity, and 2 (CT47.6, 300785 and CT47.13) are less exact but still share more than 95% nucleotide identity. Quantitative RT-PCR detected strong CT47 expression in testis, low expression in placenta, and very low expression in brain. Database analysis identified a duplicated CT47 homolog on Pan troglodytes chromosome X, but no CT47 homolog was found in nonprimate species, indicating a recent gene duplication event.
Using an accession number for CT47A11 that was provided by Strausberg et al. (2002) (GenBank BC029540), Hartz (2009) identified 12 copies of the CT47 gene. Of these, 9 share 100% nucleotide identity, and 3 share over 90.0% nucleotide identity. All contain 3 exons.
Chen et al. (2006) determined that the LOC255313 gene spans 3.3 kb and contains 3 exons, the last of which is noncoding.
By sequence analysis, Chen et al. (2006) mapped 13 tandem duplications of the CT47 gene, including LOC255313, to a 60-kb segment on the minus strand of chromosome Xq24.
Hartz (2009) mapped the duplications of the CT47 gene to chromosome Xq24 based on alignment of a sequence containing CT47A11 (GenBank AB097024) with the genomic sequence (build 36.1).
Chen, Y.-T., Iseli, C., Venditti, C. A., Old, L. J., Simpson, A. J. G., Jongeneel, C. V. Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome. Genes Chromosomes Cancer 45: 392-400, 2006. [PubMed: 16382448] [Full Text: https://doi.org/10.1002/gcc.20298]
Hartz, P. A. Personal Communication. Baltimore, Md. 6/26/2009.
Strausberg, R. L., Feingold, E. A., Grouse, L. H., Derge, J. G., Klausner, R. D., Collins, F. S., Wagner, L., Shenmen, C. M., Schuler, G. D., Altschul, S. F., Zeeberg, B., Buetow, K. H., and 71 others. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Nat. Acad. Sci. 99: 16899-16903, 2002. [PubMed: 12477932] [Full Text: https://doi.org/10.1073/pnas.242603899]