Entry - *300811 - MICRO RNA 105-1; MIR105-1 - OMIM

 
 
* 300811

MICRO RNA 105-1; MIR105-1


Alternative titles; symbols

miRNA105-1
MIRN105-1


HGNC Approved Gene Symbol: MIR105-1

Cytogenetic location: Xq28     Genomic coordinates (GRCh38): X:152,392,219-152,392,299 (from NCBI)


TEXT

▼ Description

MicroRNAs (miRNAs), such as MIR105, are endogenous noncoding RNAs of about 22 nucleotides that regulate gene expression. Two independent genes, MIR105-1 and MIR105-2 (300812), encode the same mature MIR105 sequence (Mourelatos et al., 2002).


▼ Cloning and Expression

Mourelatos et al. (2002) identified MIR105 as 1 of at least 40 miRNAs present in a large 15S RNP complex containing EIF2C2 (606229), GEMIN3 (606168), and GEMIN4 (606969). The MIR105 sequence is UCAAAUGCUCAGACUCCUGU.


▼ Mapping

By genomic sequence analysis, Mourelatos et al. (2002) mapped the MIR105-1 and MIR105-2 genes to the X chromosome.


▼ REFERENCES

  1. Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., Dreyfuss, G. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 16: 720-728, 2002. [PubMed: 11914277, images, related citations] [Full Text]


Creation Date:
Matthew B. Gross : 12/17/2009
Edit History:
mgross : 12/17/2009

* 300811

MICRO RNA 105-1; MIR105-1


Alternative titles; symbols

miRNA105-1
MIRN105-1


HGNC Approved Gene Symbol: MIR105-1

Cytogenetic location: Xq28     Genomic coordinates (GRCh38): X:152,392,219-152,392,299 (from NCBI)


TEXT

Description

MicroRNAs (miRNAs), such as MIR105, are endogenous noncoding RNAs of about 22 nucleotides that regulate gene expression. Two independent genes, MIR105-1 and MIR105-2 (300812), encode the same mature MIR105 sequence (Mourelatos et al., 2002).


Cloning and Expression

Mourelatos et al. (2002) identified MIR105 as 1 of at least 40 miRNAs present in a large 15S RNP complex containing EIF2C2 (606229), GEMIN3 (606168), and GEMIN4 (606969). The MIR105 sequence is UCAAAUGCUCAGACUCCUGU.


Mapping

By genomic sequence analysis, Mourelatos et al. (2002) mapped the MIR105-1 and MIR105-2 genes to the X chromosome.


REFERENCES

  1. Mourelatos, Z., Dostie, J., Paushkin, S., Sharma, A., Charroux, B., Abel, L., Rappsilber, J., Mann, M., Dreyfuss, G. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. Genes Dev. 16: 720-728, 2002. [PubMed: 11914277] [Full Text: https://doi.org/10.1101/gad.974702]


Creation Date:
Matthew B. Gross : 12/17/2009

Edit History:
mgross : 12/17/2009



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 30, 2024