HGNC Approved Gene Symbol: GPR19
Cytogenetic location: 12p13.1 Genomic coordinates (GRCh38): 12:12,660,890-12,717,246 (from NCBI)
O'Dowd et al. (1996) cloned a cDNA encoding a G protein-coupled receptor (see 601805) that they designated GPR19. Sequence analysis revealed that the predicted 415-amino acid GPR19 contains the 7 transmembrane domains characteristic of GPCRs. It is most closely related to members of the D2 dopamine receptor family (see 126449) and the neuropeptide Y receptors (see 162641). GPR19 is an intronless gene. O'Dowd et al. (1996) also isolated genomic clones of the rat GPR19 homolog. By Northern blot analysis, O'Dowd et al. (1996) determined that GPR19 is expressed as a 1.5-kb mRNA in human caudate nucleus, putamen, and thalamus, and as a 1.7-kb mRNA in rat brain and peripheral tissues. In situ hybridization to rat brain sections revealed that GPR19 mRNA is expressed in a pattern similar to that of the D2 receptor genes.
By fluorescence in situ hybridization, O'Dowd et al. (1996) mapped the GPR19 gene to 12p13.2-p12.3. Montpetit and Sinnett (1999) reported the physical mapping of the GPR19 gene approximately 40 kb from CDKN1B (600778). The following gene order was delineated: tel-ETV6 (600618)-CDKN1B-GPR19-cen.
Montpetit, A., Sinnett, D. Physical mapping of the G-protein coupled receptor 19 (GPR19) in the chromosome 12p12.3 region frequently rearranged in cancer cells. Hum. Genet. 105: 162-164, 1999. [PubMed: 10480372] [Full Text: https://doi.org/10.1007/s004399900083]
O'Dowd, B. F., Nguyen, T., Lynch, K. R., Kolakowski, L. F., Jr., Thompson, M., Cheng, R., Marchese, A., Ng, G., Heng, H. H. Q., George, S. R. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. FEBS Lett. 394: 325-329, 1996. [PubMed: 8830667] [Full Text: https://doi.org/10.1016/0014-5793(96)00901-5]