Alternative titles; symbols
HGNC Approved Gene Symbol: HSPA1B
Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,827,738-31,830,254 (from NCBI)
Sargent et al. (1989) identified a duplicated HSP70 locus in the class III region of the major histocompatibility complex on chromosome 6p21.3. Milner and Campbell (1990) determined that the HSP70-1 (HSPA1A; 140550) and HSP70-2 (HSPA1B) coding sequences encode identical 641-amino acid proteins. Northern blot analysis of HeLa cell RNA detected an approximately 2.4-kb HSP70-2 transcript that was expressed at elevated levels following heat shock.
Milner and Campbell (1990) determined that the HSP70-2 gene, like HSP70-1, lacks introns. The HSP70-1 and -2 coding sequences differ by 8 bp that do not alter the derived amino acid sequence; the 3-prime untranslated regions of these genes are completely divergent.
Sargent et al. (1989) identified the HSP70-1 and HSP70-2 genes in the class III region of the major histocompatibility complex on chromosome 6p21.3. The genes are 12 kb apart and lie 92 kb telomeric to the C2 gene (613927).
Milner and Campbell (1992) investigated the presence of sequence variation in the HSP70-2 gene among different HLA haplotypes. They found only very limited sequence variation, which did not result in amino acid substitutions.
Milner, C. M., Campbell, R. D. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics 32: 242-251, 1990. [PubMed: 1700760] [Full Text: https://doi.org/10.1007/BF00187095]
Milner, C. M., Campbell, R. D. Polymorphic analysis of the three MHC-linked HSP70 genes. Immunogenetics 36: 357-362, 1992. [PubMed: 1356099] [Full Text: https://doi.org/10.1007/BF00218042]
Sargent, C. A., Dunham, I., Trowsdale, J., Campbell, R. D. Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc. Nat. Acad. Sci. 86: 1968-1972, 1989. [PubMed: 2538825] [Full Text: https://doi.org/10.1073/pnas.86.6.1968]