Alternative titles; symbols
HGNC Approved Gene Symbol: LAMTOR3
Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,878,336-99,894,546 (from NCBI)
Schaeffer et al. (1998) used a 2-hybrid screen with MEK1 (176872) as bait to identify nonenzymatic components of the extracellular signal-regulated kinase (ERK) cascade that might be important in regulating its activity. The ERK cascade is one of several evolutionarily conserved mitogen-activated protein (MAP) kinase cascades important in the regulation of growth, apoptosis, and differentiation. The MAP kinases ERK1 (601795) and ERK2 (176948) are activated by the MAP kinase kinases MEK1 or MEK2 (601263). MEKs, in turn, are activated by members of the Raf family, e.g., RAF1 (164760). Schaeffer et al. (1998) identified a 13.5-kD protein, which they called MP1 (MEK partner-1). RNA blot analysis of various mouse tissues showed similar amounts of 1.4- to 1.5-kb MP1 transcript in heart, brain, lung, liver, muscle, and kidney, and smaller amounts in spleen and testis. Immunoblot analysis detected MP1 protein in various cell lines.
Schaeffer et al. (1998) found that MP1 bound specifically to MEK1 and ERK1 and facilitated their activation. When overexpressed in cultured cells, MP1 enhanced activation of ERK1 and activation of a reporter driven by the transcription factor ELK1 (311040). Expression of MP1 in cells increased binding of ERK1 to MEK1. MP1 apparently functions as an adaptor to enhance the efficiency of the MAP kinase cascade.
Gross (2012) mapped the LAMTOR3 gene to chromosome 4q23 based on an alignment of the LAMTOR3 sequence (GenBank AF130115) with the genomic sequence (GRCh37).
Gross, M. B. Personal Communication. Baltimore, Md. 6/29/2012.
Schaeffer, H. J., Catling, A. D., Eblen, S. T., Collier, L. S., Krauss, A., Weber, M. J. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281: 1668-1671, 1998. [PubMed: 9733512] [Full Text: https://doi.org/10.1126/science.281.5383.1668]