Entry - *603404 - ZINC FINGER PROTEIN 169; ZNF169 - OMIM

 
 
* 603404

ZINC FINGER PROTEIN 169; ZNF169


HGNC Approved Gene Symbol: ZNF169

Cytogenetic location: 9q22.32     Genomic coordinates (GRCh38): 9:94,259,298-94,301,829 (from NCBI)


TEXT

▼ Cloning and Expression

Using sequence tagged site (STS) mapping and somatic cell hybrid panel analysis to construct YAC contigs spanning the critical region for several disease loci on chromosome 9q22.1-q31, Chidambaram et al. (1997) identified a genomic cosmid containing a novel open reading frame (GenBank U28322, U28251), which they called ZNF169. The deduced ZNF169 protein has a region showing similarity to the A box of Kruppel-like zinc finger proteins, and 13 Kruppel-type zinc finger domains. By Northern blot analysis of human tissue RNAs, Blair et al. (1998) demonstrated that ZNF169 is highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine, and not expressed in adult brain or spinal cord.


▼ Mapping

Using fluorescence in situ hybridization and pulsed field gel electrophoresis, Levanat et al. (1997) mapped the ZNF169 gene to chromosome 9q22.3, very close to D9S196 and D9S280. Blair et al. (1998) mapped the ZNF169 gene to 9q22.1-q22.3.


▼ REFERENCES

  1. Blair, I. P., Hulme, D., Dawkins, J. L., Nicholson, G. A. A YAC-based transcript map of human chromosome 9q22.1-q22.3 encompassing the loci for hereditary sensory neuropathy type I and multiple self-healing squamous epithelioma. Genomics 51: 277-281, 1998. [PubMed: 9722951, related citations] [Full Text]

  2. Chidambaram, A., Gailani, M., Gerrard, B., Stewart, C., Goldstein, A., Chumakov, I., Bale, A. E., Dean, M. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. Genes Chromosomes Cancer 18: 212-218, 1997. [PubMed: 9071574, related citations] [Full Text]

  3. Levanat, S., Chidambaram, A., Wicking, C., Bray-Ward, P., Pressman, C., Toftgard, R., Gailani, M. R., Myers, J. C., Wainwright, B., Dean, M., Bale, A. E. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. Cytogenet. Cell Genet. 76: 208-213, 1997. [PubMed: 9186526, related citations] [Full Text]


Creation Date:
Sheryl A. Jankowski : 1/5/1999
Edit History:
carol : 12/10/2008
carol : 7/12/2007
psherman : 1/6/1999

* 603404

ZINC FINGER PROTEIN 169; ZNF169


HGNC Approved Gene Symbol: ZNF169

Cytogenetic location: 9q22.32     Genomic coordinates (GRCh38): 9:94,259,298-94,301,829 (from NCBI)


TEXT

Cloning and Expression

Using sequence tagged site (STS) mapping and somatic cell hybrid panel analysis to construct YAC contigs spanning the critical region for several disease loci on chromosome 9q22.1-q31, Chidambaram et al. (1997) identified a genomic cosmid containing a novel open reading frame (GenBank U28322, U28251), which they called ZNF169. The deduced ZNF169 protein has a region showing similarity to the A box of Kruppel-like zinc finger proteins, and 13 Kruppel-type zinc finger domains. By Northern blot analysis of human tissue RNAs, Blair et al. (1998) demonstrated that ZNF169 is highly expressed in kidney, weakly expressed in heart, liver, spleen, and small intestine, and not expressed in adult brain or spinal cord.


Mapping

Using fluorescence in situ hybridization and pulsed field gel electrophoresis, Levanat et al. (1997) mapped the ZNF169 gene to chromosome 9q22.3, very close to D9S196 and D9S280. Blair et al. (1998) mapped the ZNF169 gene to 9q22.1-q22.3.


REFERENCES

  1. Blair, I. P., Hulme, D., Dawkins, J. L., Nicholson, G. A. A YAC-based transcript map of human chromosome 9q22.1-q22.3 encompassing the loci for hereditary sensory neuropathy type I and multiple self-healing squamous epithelioma. Genomics 51: 277-281, 1998. [PubMed: 9722951] [Full Text: https://doi.org/10.1006/geno.1998.5373]

  2. Chidambaram, A., Gailani, M., Gerrard, B., Stewart, C., Goldstein, A., Chumakov, I., Bale, A. E., Dean, M. Characterization of a YAC contig containing the NBCCS locus and a novel Kruppel-type zinc finger sequence on chromosome segment 9q22.3. Genes Chromosomes Cancer 18: 212-218, 1997. [PubMed: 9071574] [Full Text: https://doi.org/10.1002/(sici)1098-2264(199703)18:3<212::aid-gcc7>3.0.co;2-4]

  3. Levanat, S., Chidambaram, A., Wicking, C., Bray-Ward, P., Pressman, C., Toftgard, R., Gailani, M. R., Myers, J. C., Wainwright, B., Dean, M., Bale, A. E. Pulsed-field gel electrophoresis and FISH mapping of chromosome 9q22: placement of a novel zinc finger gene within the NBCCS and ESS1 region. Cytogenet. Cell Genet. 76: 208-213, 1997. [PubMed: 9186526] [Full Text: https://doi.org/10.1159/000134551]


Creation Date:
Sheryl A. Jankowski : 1/5/1999

Edit History:
carol : 12/10/2008
carol : 7/12/2007
psherman : 1/6/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 25, 2024