Alternative titles; symbols
HGNC Approved Gene Symbol: SIGLEC7
Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,142,301-51,153,526 (from NCBI)
By the generation of a specific monoclonal antibody, Falco et al. (1999) identified a novel inhibitory receptor, which they designated AIRM1 (adhesion inhibitory receptor molecule-1), that is confined mostly to human natural killer cells. AIRM1 is a 467-amino acid glycoprotein with a molecular mass of 75 kD that, upon sodium pervanadate treatment, became tyrosine phosphorylated and associated with the tyrosine phosphatase SHP1 (176883). AIRM1 is a novel member of the sialoadhesin family characterized by 3 immunoglobulin-like extracellular domains (1 N-terminal V type and 2 C2 type) and a classic immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic portion. The highest amino acid sequence similarity found was with the myeloid-specific CD33 molecule (159590), and similar to other sialoadhesin molecules, AIRM1 appears to mediate sialic acid-dependent ligand recognition.
By analyzing genomic DNA samples derived from a panel of human/hamster somatic cell hybrids, Falco et al. (1999) mapped the SIGLEC7 gene to chromosome 19. They noted that other members of the sialoadhesin family map to chromosome 19, including CD33, SIGLEC6 (604405), SIGLEC5 (604200), myelin-associated glycoprotein (MAG; 159460), and CD22 (107266). Therefore, SIGLEC7 is probably located on 19q13.3, where these other family members have been localized.
Falco, M., Biassoni, R., Bottino, C., Vitale, M., Sivori, S., Augugliaro, R., Moretta, L., Moretta, A. Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. J. Exp. Med. 190: 793-801, 1999. [PubMed: 10499918] [Full Text: https://doi.org/10.1084/jem.190.6.793]