Alternative titles; symbols
HGNC Approved Gene Symbol: FZD10
Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,162,464-130,165,740 (from NCBI)
Drosophila cuticle hairs are arranged in a defined polarity that is genetically controlled by 'frizzled,' a 7-transmembrane receptor with a large extracellular N-terminal cysteine-rich domain (CRD). Members of the FZD family are receptors for secreted WNT glycoproteins (see 602863), which are involved in developmental control. FZD proteins transmit signals through the beta-catenin (CTNNB1; 116806) or JNK (e.g., JNK3; 602897) pathways. The selection of intracellular signaling cascade may be determined by different C-terminal motifs in FZD proteins.
By PCR with degenerate primers based on FZD transmembrane domain sequences, followed by screening a fetal lung cDNA library, Koike et al. (1999) obtained a cDNA encoding FZD10. The deduced 581-amino acid protein, which is 66% identical to FZD9 (601766), contains an N-terminal CRD; 7 transmembrane domains with 2 cys residues in the second and third extracellular loops; 2 N-linked glycosylation sites; and a C-terminal ser/thr-Xxx-val motif, which is a binding site for scaffold proteins with multiple PDZ domains. Northern blot analysis revealed wide expression of a 4.0-kb FZD10 transcript, with highest levels in placenta and fetal kidney, followed by fetal lung and brain. Within adult brain, expression was relatively high in cerebellum, followed by cerebral cortex, medulla, and spinal cord.
By genomic sequence analysis, Koike et al. (1999) determined that the FZD10 gene contains a single exon.
By FISH, Koike et al. (1999) mapped the FZD10 gene to 12q24.33.
Koike, J., Takagi, A., Miwa, T., Hirai, M., Terada, M., Katoh, M. Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family. Biochem. Biophys. Res. Commun. 262: 39-43, 1999. [PubMed: 10448064] [Full Text: https://doi.org/10.1006/bbrc.1999.1161]