Alternative titles; symbols
HGNC Approved Gene Symbol: ATP6V1G1
Cytogenetic location: 9q32 Genomic coordinates (GRCh38): 9:114,587,769-114,598,879 (from NCBI)
The vacuolar H(+)-ATPases, or V-ATPases, function in the acidification of intracellular compartments in eukaryotic cells. The V-ATPases are multisubunit complexes composed of 2 functional domains. ATP6V1G1 is 1 of at least 8 different subunits that make up the peripheral V1 domain, a 500-kD complex responsible for ATP hydrolysis. The integral V0 domain contains at least 5 different subunits and functions in proton translocation. For a review, see Stevens and Forgac (1997).
Zhang et al. (2000) cloned ATP6V1G1 from a hematopoietic stem/progenitor cell cDNA library prepared form umbilical cord blood. The deduced protein contains 118 amino acids, and RT-PCR showed low expression in all hematopoietic cell lines tested.
Zhang et al. (2000) determined that the ATP6V1G1 gene contains 3 exons.
The International Radiation Hybrid Mapping Consortium mapped the ATP6V1G1 gene to chromosome 9 (stSG47990).
Stevens, T. H., Forgac, M. Structure, function and regulation of the vacuolar (H+)-ATPase. Annu. Rev. Cell Dev. Biol. 13: 779-808, 1997. [PubMed: 9442887] [Full Text: https://doi.org/10.1146/annurev.cellbio.13.1.779]
Zhang, Q.-H., Ye, M., Wu, X.-Y., Ren, S.-X., Zhao, M., Zhao, C.-J., Fu, G., Shen, Y., Fan, H.-Y., Lu, G., Zhong, M., Xu, X.-R., and 9 others. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. Genome Res. 10: 1546-1560, 2000. [PubMed: 11042152] [Full Text: https://doi.org/10.1101/gr.140200]