Entry - *607503 - DISPATCHED RND TRANSPORTER FAMILY, MEMBER 2; DISP2 - OMIM

 
 
* 607503

DISPATCHED RND TRANSPORTER FAMILY, MEMBER 2; DISP2


Alternative titles; symbols

DISPATCHED, DROSOPHILA, HOMOLOG OF, 2
DISPB
KIAA1742


HGNC Approved Gene Symbol: DISP2

Cytogenetic location: 15q15.1     Genomic coordinates (GRCh38): 15:40,358,219-40,378,621 (from NCBI)


TEXT

▼ Cloning and Expression

The 'dispatched' (disp) gene is required for long-range hedgehog signaling in Drosophila. By screening mouse cDNA libraries using ESTs identified in database searches, Ma et al. (2002) isolated cDNAs encoding 2 murine homologs of dispatched, which they called Dispa (607502) and Dispb. They predicted that the dispatched proteins all have 12 transmembrane spans with cytoplasmic N and C termini.


▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the DISP2 gene to chromosome 15 (RH77781).

▼ REFERENCES

  1. Ma, Y., Erkner, A., Gong, R., Yao, S., Taipale, J., Basler, K., Beachy, P. A. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell 111: 63-75, 2002. [PubMed: 12372301, related citations] [Full Text]


Creation Date:
Stylianos E. Antonarakis : 1/23/2003
Edit History:
carol : 03/30/2020
alopez : 07/07/2006
mgross : 1/23/2003

* 607503

DISPATCHED RND TRANSPORTER FAMILY, MEMBER 2; DISP2


Alternative titles; symbols

DISPATCHED, DROSOPHILA, HOMOLOG OF, 2
DISPB
KIAA1742


HGNC Approved Gene Symbol: DISP2

Cytogenetic location: 15q15.1     Genomic coordinates (GRCh38): 15:40,358,219-40,378,621 (from NCBI)


TEXT

Cloning and Expression

The 'dispatched' (disp) gene is required for long-range hedgehog signaling in Drosophila. By screening mouse cDNA libraries using ESTs identified in database searches, Ma et al. (2002) isolated cDNAs encoding 2 murine homologs of dispatched, which they called Dispa (607502) and Dispb. They predicted that the dispatched proteins all have 12 transmembrane spans with cytoplasmic N and C termini.


Mapping

The International Radiation Hybrid Mapping Consortium mapped the DISP2 gene to chromosome 15 (RH77781).

REFERENCES

  1. Ma, Y., Erkner, A., Gong, R., Yao, S., Taipale, J., Basler, K., Beachy, P. A. Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell 111: 63-75, 2002. [PubMed: 12372301] [Full Text: https://doi.org/10.1016/s0092-8674(02)00977-7]


Creation Date:
Stylianos E. Antonarakis : 1/23/2003

Edit History:
carol : 03/30/2020
alopez : 07/07/2006
mgross : 1/23/2003



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 2, 2024