Entry - *607768 - SESTRIN 3; SESN3 - OMIM

 
 
* 607768

SESTRIN 3; SESN3


Alternative titles; symbols

SEST3


HGNC Approved Gene Symbol: SESN3

Cytogenetic location: 11q21     Genomic coordinates (GRCh38): 11:95,165,513-95,232,475 (from NCBI)


TEXT

▼ Cloning and Expression

By database mining, Peeters et al. (2003) identified a gene family related to p53-activated gene-26 (PA26; 606103), which they termed the sestrin family. Sequence alignment of human and mouse sestrin protein family members showed that the gene family is highly conserved. The SEST3 gene encodes a deduced 492-amino acid protein.


▼ Mapping

Using FISH, Peeters et al. (2003) confirmed the localization of the human sestrin genes PA26, SEST2 (607767), and SEST3 to chromosomes 6q21, 1p35.3, and 11q21, respectively. Using the same method, they mapped the mouse Pa26, Sest2, and Sest3 genes to syntenic regions on chromosomes 4, 9, and 10, respectively.


▼ REFERENCES

  1. Peeters, H., Debeer, P., Bairoch, A., Wilquet, V., Huysmans, C., Parthoens, E., Fryns, J. P., Gewillig, M., Nakamura, Y., Niikawa, N., Van de Ven, W., Devriendt, K. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. Hum. Genet. 112: 573-580, 2003. [PubMed: 12607115, related citations] [Full Text]


Creation Date:
Victor A. McKusick : 5/8/2003
Edit History:
alopez : 04/26/2010
terry : 4/22/2010
alopez : 4/30/2004
tkritzer : 5/13/2003
tkritzer : 5/12/2003

* 607768

SESTRIN 3; SESN3


Alternative titles; symbols

SEST3


HGNC Approved Gene Symbol: SESN3

Cytogenetic location: 11q21     Genomic coordinates (GRCh38): 11:95,165,513-95,232,475 (from NCBI)


TEXT

Cloning and Expression

By database mining, Peeters et al. (2003) identified a gene family related to p53-activated gene-26 (PA26; 606103), which they termed the sestrin family. Sequence alignment of human and mouse sestrin protein family members showed that the gene family is highly conserved. The SEST3 gene encodes a deduced 492-amino acid protein.


Mapping

Using FISH, Peeters et al. (2003) confirmed the localization of the human sestrin genes PA26, SEST2 (607767), and SEST3 to chromosomes 6q21, 1p35.3, and 11q21, respectively. Using the same method, they mapped the mouse Pa26, Sest2, and Sest3 genes to syntenic regions on chromosomes 4, 9, and 10, respectively.


REFERENCES

  1. Peeters, H., Debeer, P., Bairoch, A., Wilquet, V., Huysmans, C., Parthoens, E., Fryns, J. P., Gewillig, M., Nakamura, Y., Niikawa, N., Van de Ven, W., Devriendt, K. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse. Hum. Genet. 112: 573-580, 2003. [PubMed: 12607115] [Full Text: https://doi.org/10.1007/s00439-003-0917-5]


Creation Date:
Victor A. McKusick : 5/8/2003

Edit History:
alopez : 04/26/2010
terry : 4/22/2010
alopez : 4/30/2004
tkritzer : 5/13/2003
tkritzer : 5/12/2003



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 10, 2024