Entry - *608016 - CYTOCHROME c OXIDASE ASSEMBLY FACTOR 4 HOMOLOG; COA4 - OMIM

 
 
* 608016

CYTOCHROME c OXIDASE ASSEMBLY FACTOR 4 HOMOLOG; COA4


Alternative titles; symbols

COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 8; CHCHD8
E2-INDUCED GENE 2; E2IG2


HGNC Approved Gene Symbol: COA4

Cytogenetic location: 11q13.4     Genomic coordinates (GRCh38): 11:73,872,667-73,876,846 (from NCBI)


TEXT

▼ Cloning and Expression

To identify genes that are regulated by or associated with estrogen action, Charpentier et al. (2000) performed serial analysis of gene expression (SAGE) on estrogen-responsive breast cancer cells after exposure to estrogen. Using transcript-specific PCR primers for novel sequences that increased more than 10-fold upon treatment with 17-beta estradiol (E2), they cloned 5 cDNAs, designated E2-induced genes (E2IG) 1-5, from a human placenta cDNA library. The E2IG2 cDNA encodes a deduced 97-amino acid protein.


▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the E2IG2 gene to chromosome 11 (STS-T99047).

▼ REFERENCES

  1. Charpentier, A. H., Bednarek, A. K., Daniel, R. L., Hawkins, K. A., Laflin, K. J., Gaddis, S., MacLeod, M. C., Aldaz, C. M. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res. 60: 5977-5983, 2000. [PubMed: 11085516, related citations] [Full Text]


Creation Date:
Carol A. Bocchini : 8/6/2003
Edit History:
carol : 08/12/2020
carol : 06/05/2007
carol : 1/12/2007
tkritzer : 8/7/2003
carol : 8/6/2003

* 608016

CYTOCHROME c OXIDASE ASSEMBLY FACTOR 4 HOMOLOG; COA4


Alternative titles; symbols

COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN-CONTAINING PROTEIN 8; CHCHD8
E2-INDUCED GENE 2; E2IG2


HGNC Approved Gene Symbol: COA4

Cytogenetic location: 11q13.4     Genomic coordinates (GRCh38): 11:73,872,667-73,876,846 (from NCBI)


TEXT

Cloning and Expression

To identify genes that are regulated by or associated with estrogen action, Charpentier et al. (2000) performed serial analysis of gene expression (SAGE) on estrogen-responsive breast cancer cells after exposure to estrogen. Using transcript-specific PCR primers for novel sequences that increased more than 10-fold upon treatment with 17-beta estradiol (E2), they cloned 5 cDNAs, designated E2-induced genes (E2IG) 1-5, from a human placenta cDNA library. The E2IG2 cDNA encodes a deduced 97-amino acid protein.


Mapping

The International Radiation Hybrid Mapping Consortium mapped the E2IG2 gene to chromosome 11 (STS-T99047).

REFERENCES

  1. Charpentier, A. H., Bednarek, A. K., Daniel, R. L., Hawkins, K. A., Laflin, K. J., Gaddis, S., MacLeod, M. C., Aldaz, C. M. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res. 60: 5977-5983, 2000. [PubMed: 11085516] [Full Text: http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=11085516]


Creation Date:
Carol A. Bocchini : 8/6/2003

Edit History:
carol : 08/12/2020
carol : 06/05/2007
carol : 1/12/2007
tkritzer : 8/7/2003
carol : 8/6/2003



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 24, 2024