Alternative titles; symbols
DO: 0070088;
Cytogenetic location: 1p36.2 Genomic coordinates (GRCh38): 1:7,100,001-15,900,000
| Location | Phenotype |
Phenotype MIM number |
Inheritance |
Phenotype mapping key |
|---|---|---|---|---|
| 1p36.2 | {Schizophrenia 12} | 181500 | Autosomal dominant | 2 |
For a phenotypic description and a discussion of genetic heterogeneity of schizophrenia, see 181500.
Using both nonparametric and parametric linkage analyses to analyze 34 Afrikaner families with schizophrenia, Abecasis et al. (2004) identified a susceptibility locus on chromosome 1p (maximum lod score of 3.30 at marker D1S1612). Abecasis et al. (2004) noted that this locus is distinct from the schizophrenia locus on chromosome 1q (SCZD9; 604906). Close inspection revealed that 1 affected proband had paternal isodisomy for the entire chromosome 1.
Abecasis, G. R., Burt, R. A., Hall, D., Bochum, S., Doheny, K. F., Lundy, S. L., Torrington, M., Roos, J. L., Gogos, J. A., Karayiorgou, M. Genomewide scan in families with schizophrenia from the founder population of Afrikaners reveals evidence for linkage and uniparental disomy on chromosome 1. Am. J. Hum. Genet. 74: 403-417, 2004. [PubMed: 14750073] [Full Text: https://doi.org/10.1086/381713]