Alternative titles; symbols
HGNC Approved Gene Symbol: FBXO21
Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:117,141,991-117,190,470 (from NCBI)
Members of the F-box protein family, such as FBXO21, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (601434), cullin (see CUL1; 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).
By sequencing clones obtained from a size-fractionated brain cDNA library, Nagase et al. (1998) obtained a partial FBXO21 clone, which they designated KIAA0875. RT-PCR detected high expression of FBXO21 in all tissues examined, including heart, brain, kidney, spleen, testis, ovary, lung, skeletal muscle, and pancreas.
Jin et al. (2004) reported that the FBXO21 protein contains an F box in its N-terminal half.
By radiation hybrid analysis, Nagase et al. (1998) mapped the FBXO21 gene to chromosome 12. Jin et al. (2004) stated that the FBXO21 gene maps to chromosome 12q24.23 and the mouse Fbxo21 gene maps to chromosome 5F.
Jin, J., Cardozo, T., Lovering, R. C., Elledge, S. J., Pagano, M., Harper, J. W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573-2580, 2004. [PubMed: 15520277] [Full Text: https://doi.org/10.1101/gad.1255304]
Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Oharo, O. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 355-364, 1998. [PubMed: 10048485] [Full Text: https://doi.org/10.1093/dnares/5.6.355]