Entry - *609106 - F-BOX ONLY PROTEIN 39; FBXO39 - OMIM

 
 
* 609106

F-BOX ONLY PROTEIN 39; FBXO39


Alternative titles; symbols

FBX39


HGNC Approved Gene Symbol: FBXO39

Cytogenetic location: 17p13.1     Genomic coordinates (GRCh38): 17:6,776,215-6,787,646 (from NCBI)


TEXT

▼ Description

Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (601434), cullin (see CUL1; 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).


▼ Cloning and Expression

Jin et al. (2004) reported that the FBXO39 protein contains an N-terminal F box, followed by a domain that may form a structure similar to that formed by the leucine-rich repeats in placental RNase inhibitor (RNH; 173320).


▼ Mapping

Jin et al. (2004) stated that the FBXO39 gene maps to chromosome 17p13.2 and the mouse Fbxo39 gene maps to chromosome 11B4.


▼ REFERENCES

  1. Jin, J., Cardozo, T., Lovering, R. C., Elledge, S. J., Pagano, M., Harper, J. W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573-2580, 2004. [PubMed: 15520277, images, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 12/14/2004
Edit History:
mgross : 12/15/2004

* 609106

F-BOX ONLY PROTEIN 39; FBXO39


Alternative titles; symbols

FBX39


HGNC Approved Gene Symbol: FBXO39

Cytogenetic location: 17p13.1     Genomic coordinates (GRCh38): 17:6,776,215-6,787,646 (from NCBI)


TEXT

Description

Members of the F-box protein family, such as FBXO39, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (601434), cullin (see CUL1; 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004).


Cloning and Expression

Jin et al. (2004) reported that the FBXO39 protein contains an N-terminal F box, followed by a domain that may form a structure similar to that formed by the leucine-rich repeats in placental RNase inhibitor (RNH; 173320).


Mapping

Jin et al. (2004) stated that the FBXO39 gene maps to chromosome 17p13.2 and the mouse Fbxo39 gene maps to chromosome 11B4.


REFERENCES

  1. Jin, J., Cardozo, T., Lovering, R. C., Elledge, S. J., Pagano, M., Harper, J. W. Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 18: 2573-2580, 2004. [PubMed: 15520277] [Full Text: https://doi.org/10.1101/gad.1255304]


Creation Date:
Patricia A. Hartz : 12/14/2004

Edit History:
mgross : 12/15/2004



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 28, 2024