Alternative titles; symbols
HGNC Approved Gene Symbol: METTL9
Cytogenetic location: 16p12.2 Genomic coordinates (GRCh38): 16:21,597,208-21,657,471 (from NCBI)
Bates et al. (2000) identified ESTs containing sequences complementary to the region 5-prime of the mouse and human IGSF6 genes (606222). The deduced proteins, designated DREV (DORA reverse strand) proteins, show weak homology to ribosomal RNA adenine dimethylases and contain conserved consensus sequences for the recognition of nucleotide methyl groups and possibly for methyl group transfer. Northern blot analysis of mouse tissues detected ubiquitous and variable Drev expression.
Bates et al. (2000) determined that the DREV gene contains 5 exons. The 5-prime UTR has a high GC content. Intron 4 of the DREV gene contains the entire IGSF6 gene on the complementary strand, and there is a retrotransposon-like sequence between the 3-prime end of the IGSF6 gene and exon 4 of the DREV gene.
By FISH, Bates et al. (2000) mapped the mouse Drev gene to a region of chromosome 7F2-F3 that shows homology of synteny with human chromosome 16p12-p11. Bates et al. (1998) had earlier mapped the human IGSF6 gene to chromosome 16p13.
Bates, E. E. M., Dieu, M.-C., Ravel, O., Zurawski, S. M., Patel, S., Bridon, J.-M., Ait-Yahia, S., Vega, F., Jr., Banchereau, J., Lebecque, S. CD40L activation of dendritic cells down-regulates DORA, a novel member of the immunoglobulin superfamily. Molec. Immun. 35: 513-524, 1998. [PubMed: 9809579] [Full Text: https://doi.org/10.1016/s0161-5890(98)00045-5]
Bates, E. E. M., Kissenpfennig, A., Peronne, C., Mattei, M.-G., Fossiez, F., Malissen, B., Lebecque, S. The mouse and human IGSF6 (DORA) genes map to the inflammatory bowel disease 1 locus and are embedded in an intron of a gene of unknown function. Immunogenetics 52: 112-120, 2000. [PubMed: 11132146] [Full Text: https://doi.org/10.1007/s002510000259]