Entry - %609403 - PREECLAMPSIA/ECLAMPSIA 3; PEE3 - OMIM

 
ICD+
% 609403

PREECLAMPSIA/ECLAMPSIA 3; PEE3


Cytogenetic location: 9p13     Genomic coordinates (GRCh38): 9:33,200,001-39,000,000


Gene-Phenotype Relationships
Location Phenotype Phenotype
MIM number 		Inheritance Phenotype
mapping key
9p13 Preeclampsia/eclampsia 3 609403 2

▼ TEXT

For a general phenotypic description and a discussion of genetic heterogeneity of preeclampsia, see PEE1 (189800).

▼ Mapping

Hypothesizing that the genetic background of preeclampsia might show reduced heterogeneity in a founder population such as that of the Kainuu province in central eastern Finland, Laivuori et al. (2003) performed a genomewide scan in 15 multiplex families in that area. They found 2 loci that exceeded the threshold for significant linkage: 2p25, at 21.70 cM (PEE2; 609402), and 9p13 (PEE3), at 38.90 cM.


▼ REFERENCES

  1. Laivuori, H., Lahermo, P., Ollikainen, V., Widen, E., Haiva-Mallinen, L., Sundstrom, H., Laitinen, T., Kaaja, R., Ylikorkala, O., Kere, J. Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am. J. Hum. Genet. 72: 168-177, 2003. [PubMed: 12474145, images, related citations] [Full Text]


Creation Date:
Anne M. Stumpf : 6/7/2005
Edit History:
carol : 07/11/2011
carol : 6/8/2005
alopez : 6/8/2005

% 609403

PREECLAMPSIA/ECLAMPSIA 3; PEE3


ORPHA: 275555;   DO: 10591;  


Cytogenetic location: 9p13     Genomic coordinates (GRCh38): 9:33,200,001-39,000,000


Gene-Phenotype Relationships

Location Phenotype Phenotype
MIM number 		Inheritance Phenotype
mapping key
9p13 Preeclampsia/eclampsia 3 609403 2

TEXT

For a general phenotypic description and a discussion of genetic heterogeneity of preeclampsia, see PEE1 (189800).

Mapping

Hypothesizing that the genetic background of preeclampsia might show reduced heterogeneity in a founder population such as that of the Kainuu province in central eastern Finland, Laivuori et al. (2003) performed a genomewide scan in 15 multiplex families in that area. They found 2 loci that exceeded the threshold for significant linkage: 2p25, at 21.70 cM (PEE2; 609402), and 9p13 (PEE3), at 38.90 cM.


REFERENCES

  1. Laivuori, H., Lahermo, P., Ollikainen, V., Widen, E., Haiva-Mallinen, L., Sundstrom, H., Laitinen, T., Kaaja, R., Ylikorkala, O., Kere, J. Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families. Am. J. Hum. Genet. 72: 168-177, 2003. [PubMed: 12474145] [Full Text: https://doi.org/10.1086/345311]


Creation Date:
Anne M. Stumpf : 6/7/2005

Edit History:
carol : 07/11/2011
carol : 6/8/2005
alopez : 6/8/2005



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 24, 2024