Alternative titles; symbols
HGNC Approved Gene Symbol: KRT79
Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:52,821,408-52,834,311 (from NCBI)
Keratins, such as KRT6L, are filament proteins that make up one of the major structural fibers of epithelial cells (Rogers et al., 2005).
Using database analysis to identify keratin genes within the type II keratin gene domain on chromosome 12, Rogers et al. (2005) identified KRT6L, which they called K6L. The deduced 535-amino acid protein has a calculated molecular mass of 57.8 kD. Like other type II keratins, K6L has N- and C-terminal domains and a central rod domain consisting of 4 alpha-helical regions separated by 3 non-helical linker sequences. In addition, it has numerous GGG and GGX repeats in its head and tail domains. Northern blot analysis detected expression of a 2.1-kb K6L transcript in skeletal muscle, skin, and scalp, but not in any other tissues or organs examined.
By genomic sequence analysis, Rogers et al. (2005) mapped the KRT6L gene to chromosome 12q13.13.
Rogers, M. A., Edler, L., Winter, H., Langbein, L., Beckmann, I., Schweizer, J. Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13. J. Invest. Derm. 124: 536-544, 2005. [PubMed: 15737194] [Full Text: https://doi.org/10.1111/j.0022-202X.2004.23530.x]