Entry - *611244 - tRNA METHYLTRANSFERASE 12 HOMOLOG; TRMT12 - OMIM

 
 
* 611244

tRNA METHYLTRANSFERASE 12 HOMOLOG; TRMT12


Alternative titles; symbols

tRNA METHYLTRANSFERASE 12, S. CEREVISIAE, HOMOLOG OF
TRM12
tRNA-WYBUTOSINE-SYNTHESIZING PROTEIN 2, S. CEREVISIAE, HOMOLOG OF; TYW2
tRNA-YW-SYNTHESIZING PROTEIN 2, S. CEREVISIAE, HOMOLOG OF


HGNC Approved Gene Symbol: TRMT12

Cytogenetic location: 8q24.13     Genomic coordinates (GRCh38): 8:124,450,820-124,453,026 (from NCBI)


TEXT

▼ Description

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).


▼ Cloning and Expression

By searching databases for homologs of yeast Trm12, Kalhor et al. (2005) identified human TRMT12.


▼ Mapping

The International Radiation Hybrid Mapping Consortium mapped the TRMT12 gene to chromosome 8 (D8S1919).

▼ REFERENCES

  1. Kalhor, H. R., Penjwini, M., Clarke, S. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. Biochem. Biophys. Res. Commun. 334: 433-440, 2005. [PubMed: 16005430, related citations] [Full Text]

  2. Noma, A., Suzuki, T. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Nucleic Acids Symp. Ser. 50: 65-66, 2006. [PubMed: 17150819, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 7/24/2007
Edit History:
carol : 09/10/2019
mgross : 07/24/2007

* 611244

tRNA METHYLTRANSFERASE 12 HOMOLOG; TRMT12


Alternative titles; symbols

tRNA METHYLTRANSFERASE 12, S. CEREVISIAE, HOMOLOG OF
TRM12
tRNA-WYBUTOSINE-SYNTHESIZING PROTEIN 2, S. CEREVISIAE, HOMOLOG OF; TYW2
tRNA-YW-SYNTHESIZING PROTEIN 2, S. CEREVISIAE, HOMOLOG OF


HGNC Approved Gene Symbol: TRMT12

Cytogenetic location: 8q24.13     Genomic coordinates (GRCh38): 8:124,450,820-124,453,026 (from NCBI)


TEXT

Description

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).


Cloning and Expression

By searching databases for homologs of yeast Trm12, Kalhor et al. (2005) identified human TRMT12.


Mapping

The International Radiation Hybrid Mapping Consortium mapped the TRMT12 gene to chromosome 8 (D8S1919).

REFERENCES

  1. Kalhor, H. R., Penjwini, M., Clarke, S. A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. Biochem. Biophys. Res. Commun. 334: 433-440, 2005. [PubMed: 16005430] [Full Text: https://doi.org/10.1016/j.bbrc.2005.06.111]

  2. Noma, A., Suzuki, T. Ribonucleome analysis identified enzyme genes responsible for wybutosine synthesis. Nucleic Acids Symp. Ser. 50: 65-66, 2006. [PubMed: 17150819] [Full Text: https://doi.org/10.1093/nass/nrl032]


Creation Date:
Patricia A. Hartz : 7/24/2007

Edit History:
carol : 09/10/2019
mgross : 07/24/2007



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: April 19, 2024