Entry - *611517 - CYTOCHROME P450, FAMILY 4, SUBFAMILY F, POLYPEPTIDE 11; CYP4F11 - OMIM

 
 
* 611517

CYTOCHROME P450, FAMILY 4, SUBFAMILY F, POLYPEPTIDE 11; CYP4F11


Alternative titles; symbols

CYTOCHROME P450, SUBFAMILY IVF, POLYPEPTIDE 11


HGNC Approved Gene Symbol: CYP4F11

Cytogenetic location: 19p13.12     Genomic coordinates (GRCh38): 19:15,912,377-15,934,867 (from NCBI)


TEXT

▼ Description

CYP4F11 is a member of the CYP4F family of P450 enzymes (see CYP4F2; 604426) (Cui et al., 2000).


▼ Cloning and Expression

By screening a human hippocampus cDNA library with rat Cyp4f6 cDNA as probe, followed by RT-PCR, Cui et al. (2000) cloned full-length CYP4F11. The deduced 524-amino acid protein shares 80%, 82.3%, and 79.2% amino acid identity with CYP4F2, CYP4F3 (601270), and CYP4F8 (611545), respectively. In vitro translation produced a 57-kD protein. Northern blot analysis of human tissues detected a major 1.8-kb transcript and additional 2.5- and 2.8-kb transcripts with strong expression in liver, followed by moderate expression of the 2.8-kb transcript in kidney, and very low expression in heart, skeletal muscle, and placenta.


▼ Gene Structure

Cui et al. (2000) determined that the CYP4F11 gene contains 12 exons.


▼ Mapping

Gross (2018) mapped the CYP4F11 gene to chromosome 19p13.12 based on an alignment of the CYP4F11 sequence (GenBank AF236085) with the genomic sequence (GRCh38).

▼ REFERENCES

  1. Cui, X., Nelson, D. R., Strobel, H. W. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. Genomics 68: 161-166, 2000. [PubMed: 10964514, related citations] [Full Text]

  2. Gross, M. B. Personal Communication. Baltimore, Md. 4/9/2018.


Contributors:
Matthew B. Gross - updated : 04/09/2018
Creation Date:
Dorothy S. Reilly : 10/10/2007
Edit History:
mgross : 04/09/2018
wwang : 10/22/2007
carol : 10/16/2007
wwang : 10/10/2007
wwang : 10/10/2007

* 611517

CYTOCHROME P450, FAMILY 4, SUBFAMILY F, POLYPEPTIDE 11; CYP4F11


Alternative titles; symbols

CYTOCHROME P450, SUBFAMILY IVF, POLYPEPTIDE 11


HGNC Approved Gene Symbol: CYP4F11

Cytogenetic location: 19p13.12     Genomic coordinates (GRCh38): 19:15,912,377-15,934,867 (from NCBI)


TEXT

Description

CYP4F11 is a member of the CYP4F family of P450 enzymes (see CYP4F2; 604426) (Cui et al., 2000).


Cloning and Expression

By screening a human hippocampus cDNA library with rat Cyp4f6 cDNA as probe, followed by RT-PCR, Cui et al. (2000) cloned full-length CYP4F11. The deduced 524-amino acid protein shares 80%, 82.3%, and 79.2% amino acid identity with CYP4F2, CYP4F3 (601270), and CYP4F8 (611545), respectively. In vitro translation produced a 57-kD protein. Northern blot analysis of human tissues detected a major 1.8-kb transcript and additional 2.5- and 2.8-kb transcripts with strong expression in liver, followed by moderate expression of the 2.8-kb transcript in kidney, and very low expression in heart, skeletal muscle, and placenta.


Gene Structure

Cui et al. (2000) determined that the CYP4F11 gene contains 12 exons.


Mapping

Gross (2018) mapped the CYP4F11 gene to chromosome 19p13.12 based on an alignment of the CYP4F11 sequence (GenBank AF236085) with the genomic sequence (GRCh38).

REFERENCES

  1. Cui, X., Nelson, D. R., Strobel, H. W. A novel human cytochrome P450 4F isoform (CYP4F11): cDNA cloning, expression, and genomic structural characterization. Genomics 68: 161-166, 2000. [PubMed: 10964514] [Full Text: https://doi.org/10.1006/geno.2000.6276]

  2. Gross, M. B. Personal Communication. Baltimore, Md. 4/9/2018.


Contributors:
Matthew B. Gross - updated : 04/09/2018

Creation Date:
Dorothy S. Reilly : 10/10/2007

Edit History:
mgross : 04/09/2018
wwang : 10/22/2007
carol : 10/16/2007
wwang : 10/10/2007
wwang : 10/10/2007



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 7, 2024