HGNC Approved Gene Symbol: NBPF14
Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:148,531,385-148,596,011 (from NCBI)
NBPF14 is a member of the NBPF gene family, which consists of 22 genes and pseudogenes that arose by gene duplication. NBPF genes contain numerous low-copy repetitive elements and show high intergenic and intragenic sequence identity in coding and noncoding regions (Vandepoele et al., 2005).
By searching an EST database for sequences similar to NBPF1 (610501), Vandepoele et al. (2005) identified NBPF14. EST database analysis revealed NBPF14 expression in fetal liver/spleen, prostate, uterus, and leiomyosarcoma.
Vandepoele et al. (2005) determined that the NBPF14 gene contains at least 22 coding exons, several of which result from internal duplication.
By genomic sequence analysis and FISH, Vandepoele et al. (2005) mapped the NBPF14 gene to an NBPF gene cluster on chromosome 1q21.1.
Vandepoele, K., Van Roy, N., Staes, K., Speleman, F., van Roy, F. A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution. Molec. Biol. Evol. 22: 2265-2274, 2005. [PubMed: 16079250] [Full Text: https://doi.org/10.1093/molbev/msi222]