HGNC Approved Gene Symbol: ASB7
Cytogenetic location: 15q26.3 Genomic coordinates (GRCh38): 15:100,602,589-100,651,701 (from NCBI)
Proteins of the ASB family, such as ASB7, contain central tandem ankyrin (see 612641) repeats and a C-terminal suppressor of cytokine signaling (SOCS) box. SOCS box proteins are predicted to be involved in protein degradation by acting as a bridge between substrate proteins and E3 ubiquitin protein ligases (see 601623) (review by Kile et al., 2002).
Kile et al. (2001) showed that the deduced 318-amino acid mouse Asb7 protein contains 7 ankyrin repeats and a C-terminal SOCS box.
Kohroki et al. (2005) found that epitope-tagged ASB7 and several other ASB family members interacted with endogenous CUL5 (601741) and RBX2 (RNF7; 603863) in immunoprecipitated HEK293 cells. The ASB proteins did not interact with CUL2 (603135) or RBX1 (603814).
Hartz (2013) mapped the ASB7 gene to chromosome 15q26.3 based on an alignment of the ASB7 sequence (GenBank AK026204) with the genomic sequence (GRCh37).
Hartz, P. A. Personal Communication. Baltimore, Md. 1/29/2013.
Kile, B. T., Metcalf, D., Mifsud, S., DiRago, L., Nicola, N. A., Hilton, D. J., Alexander, W. S. Functional analysis of Asb-1 using genetic modification in mice. Molec. Cell. Biol. 21: 6189-6197, 2001. [PubMed: 11509662] [Full Text: https://doi.org/10.1128/MCB.21.18.6189-6197.2001]
Kile, B. T., Schulman, B. A., Alexander, W. S., Nicola, N. A., Martin, H. M. E., Hilton, D. J. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci. 27: 235-241, 2002. [PubMed: 12076535] [Full Text: https://doi.org/10.1016/s0968-0004(02)02085-6]
Kohroki, J., Nishiyama, T., Nakamura, T., Masuho, Y. ASB proteins interact with cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. FEBS Lett. 579: 6796-6802, 2005. [PubMed: 16325183] [Full Text: https://doi.org/10.1016/j.febslet.2005.11.016]