Entry - *617704 - CANCER SUSCEPTIBILITY CANDIDATE 11, NONCODING; CASC11 - OMIM

 
 
* 617704

CANCER SUSCEPTIBILITY CANDIDATE 11, NONCODING; CASC11


Alternative titles; symbols

LONG INTERGENIC NONCODING RNA 990; LINC00990
lincRNA 990
CANCER-ASSOCIATED REGION LONG NONCODING RNA 7; CARLO7


HGNC Approved Gene Symbol: CASC11

Cytogenetic location: 8q24.21     Genomic coordinates (GRCh38): 8:127,700,608-127,733,967 (from NCBI)


TEXT

▼ Description

Long noncoding RNAs (lncRNAs), such as CASC11, are transcripts longer than 200 bp that have no protein-coding potential and function in various cellular processes (Kim et al., 2014).


▼ Cloning and Expression

By sequence analysis and RACE with human colorectal cancer-derived cells, Kim et al. (2014) identified several lncRNAs, including CASC11, which they called CARLO7, in a region of chromosome 8q24.21 that harbors cancer-associated variants and enhancer activity. They obtained 3 CARLO7 variants.


▼ Gene Structure

Kim et al. (2014) reported that CASC11 contains at least 6 exons.


▼ Mapping

By sequence analysis, Kim et al. (2014) mapped the CASC11 gene to a region of chromosome 8q24.21 that lacks protein-coding genes.


▼ REFERENCES

  1. Kim, T., Cui, R., Jeon, Y.-J., Lee, J.-H., Lee, J. H., Sim, H., Park, J. K., Fadda, P., Tili, E., Nakanishi, H., Huh, M.-I., Kim, S.-H., and 12 others. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc. Nat. Acad. Sci. 111: 4173-4178, 2014. [PubMed: 24594601, related citations] [Full Text]


Creation Date:
Matthew B. Gross : 09/28/2017
Edit History:
mgross : 09/28/2017

* 617704

CANCER SUSCEPTIBILITY CANDIDATE 11, NONCODING; CASC11


Alternative titles; symbols

LONG INTERGENIC NONCODING RNA 990; LINC00990
lincRNA 990
CANCER-ASSOCIATED REGION LONG NONCODING RNA 7; CARLO7


HGNC Approved Gene Symbol: CASC11

Cytogenetic location: 8q24.21     Genomic coordinates (GRCh38): 8:127,700,608-127,733,967 (from NCBI)


TEXT

Description

Long noncoding RNAs (lncRNAs), such as CASC11, are transcripts longer than 200 bp that have no protein-coding potential and function in various cellular processes (Kim et al., 2014).


Cloning and Expression

By sequence analysis and RACE with human colorectal cancer-derived cells, Kim et al. (2014) identified several lncRNAs, including CASC11, which they called CARLO7, in a region of chromosome 8q24.21 that harbors cancer-associated variants and enhancer activity. They obtained 3 CARLO7 variants.


Gene Structure

Kim et al. (2014) reported that CASC11 contains at least 6 exons.


Mapping

By sequence analysis, Kim et al. (2014) mapped the CASC11 gene to a region of chromosome 8q24.21 that lacks protein-coding genes.


REFERENCES

  1. Kim, T., Cui, R., Jeon, Y.-J., Lee, J.-H., Lee, J. H., Sim, H., Park, J. K., Fadda, P., Tili, E., Nakanishi, H., Huh, M.-I., Kim, S.-H., and 12 others. Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proc. Nat. Acad. Sci. 111: 4173-4178, 2014. [PubMed: 24594601] [Full Text: https://doi.org/10.1073/pnas.1400350111]


Creation Date:
Matthew B. Gross : 09/28/2017

Edit History:
mgross : 09/28/2017



NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 22, 2024