Alternative titles; symbols
HGNC Approved Gene Symbol: CCDC7
Cytogenetic location: 10p11.22 Genomic coordinates (GRCh38): 10:32,443,324-32,882,864 (from NCBI)
CCDC7 is a coiled-coil domain-containing protein that is specifically expressed in testis (Wang et al., 2009).
Wang et al. (2009) cloned mouse Ccdc7, which they called Biot2, and identified its orthologs in various species, including human. The deduced mouse Biot2 protein contains 160 amino acids and has a coiled coiled-coil domain that is conserved in its orthologs. RT-PCR analysis of mouse tissues showed that Biot2 was exclusively expressed in testis. Biot2 expression was also detected in some cancer cell lines.
Wang et al. (2009) found that knockdown of BIOT2 significantly reduced the proliferation rate in cultured human cancer cells in vitro and inhibited tumor growth in a mouse model in vivo.
Gross (2021) mapped the CCDC7 gene to chromosome 10p11.22 based on an alignment of the CCDC7 sequence (GenBank BC022020) with the genomic sequence (GRCh38).
Wang et al. (2009) mapped the mouse Ccdc7 gene to chromosome 8.
Gross, M. B. Personal Communication. Baltimore, Md. 7/20/2021.
Wang, C.-T., Zhang, P., Wang, Y.-S., Ruan, X.-Z., Li, Z.-Y., Peng, F., Yang, H.-S., Wei, Y.-Q. RNA interference against Biot2, a novel mouse testis-specific gene, inhibits the growth of tumor cells. Cell. Molec. Biol. Lett. 14: 363-376, 2009. [PubMed: 19277478] [Full Text: https://doi.org/10.2478/s11658-009-0004-6]