Entry - *620143 - TRANSMEMBRANE PROTEIN 232; TMEM232 - OMIM

 
 
* 620143

TRANSMEMBRANE PROTEIN 232; TMEM232


HGNC Approved Gene Symbol: TMEM232

Cytogenetic location: 5q22.1     Genomic coordinates (GRCh38): 5:110,387,431-110,738,954 (from NCBI)


TEXT

▼ Description

Members of the transmembrane (TMEM) protein family, such as TMEM232, are components of cellular membranes, including mitochondrial membranes, endoplasmic reticulum, lysosomes, and the Golgi apparatus (Zheng et al., 2021).


▼ Gene Function

Using Western blot analysis, Zheng et al. (2021) found that levels of the T helper-2 cytokines IL4 (147780) and IL13 (147683) increased following overexpression of TMEM232 and decreased following knockdown of TMEM232 in HaCaT keratinocytes.


▼ Mapping

Zheng et al. (2021) stated that the TMEM232 gene maps to chromosome 5q22.1.


▼ REFERENCES

  1. Zheng, J., Wu, Y. Y., Fang, W. L., Cai, X. Y., Zhang, Z. Y., Yu, C. X., Zheng, X. D., Xiao, F. L. Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing. Sci. Rep. 11: 21830, 2021. [PubMed: 34750414, related citations] [Full Text]


Creation Date:
Matthew B. Gross : 11/29/2022
Edit History:
carol : 11/29/2022
mgross : 11/29/2022

* 620143

TRANSMEMBRANE PROTEIN 232; TMEM232


HGNC Approved Gene Symbol: TMEM232

Cytogenetic location: 5q22.1     Genomic coordinates (GRCh38): 5:110,387,431-110,738,954 (from NCBI)


TEXT

Description

Members of the transmembrane (TMEM) protein family, such as TMEM232, are components of cellular membranes, including mitochondrial membranes, endoplasmic reticulum, lysosomes, and the Golgi apparatus (Zheng et al., 2021).


Gene Function

Using Western blot analysis, Zheng et al. (2021) found that levels of the T helper-2 cytokines IL4 (147780) and IL13 (147683) increased following overexpression of TMEM232 and decreased following knockdown of TMEM232 in HaCaT keratinocytes.


Mapping

Zheng et al. (2021) stated that the TMEM232 gene maps to chromosome 5q22.1.


REFERENCES

  1. Zheng, J., Wu, Y. Y., Fang, W. L., Cai, X. Y., Zhang, Z. Y., Yu, C. X., Zheng, X. D., Xiao, F. L. Confirming the TMEM232 gene associated with atopic dermatitis through targeted capture sequencing. Sci. Rep. 11: 21830, 2021. [PubMed: 34750414] [Full Text: https://doi.org/10.1038/s41598-021-01194-6]


Creation Date:
Matthew B. Gross : 11/29/2022

Edit History:
carol : 11/29/2022
mgross : 11/29/2022



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 19, 2024