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Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability at MOI of 0.01 incubated for 48 hrs by plaque formation assay
Assay data:2 Tested
SummaryPubMed Citation
Cytotoxicity against golden hamster BSR cells assessed as reduction in cell viability incubated for 24 hrs by microplate luminometer method
Assay data:33 Tested
Cytotoxicity against hamster BHK-21 cells
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability incubated for 24 hrs by Celltiter assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Oral bioavailability in hamster
Assay data:1 Tested
Cytotoxicity against golden hamster BHK-21 cells measured after 6 days by MTT assay
Assay data:29 Tested
Antibacterial activity against Clostridioides difficile UNT-103-1 infected in Syrian hamster assessed as mortality at 20 mg/kg, po administered once a daily for 5 days after 18 hrs post 10 mg/kg clindamycin treatment and measured upto 21 days
Antibacterial activity against Clostridioides difficile UNT-103-1 infected in Syrian hamster assessed as mortality at 100 mg/kg, po administered once a daily for 5 days after 18 hrs post 10 mg/kg clindamycin treatment and measured upto 21 days
Antibacterial activity against Clostridioides difficile UNT-103-1 infected in Syrian hamster assessed as mortality at 5 mg/kg, po administered once a daily for 5 days after 18 hrs post 10 mg/kg clindamycin treatment and measured after 7 to 9 days
Antibacterial activity against Clostridioides difficile UNT-103-1 infected in Syrian hamster assessed as survival at 5 mg/kg, po administered once a daily for 5 days after 18 hrs post 10 mg/kg clindamycin treatment
Antibacterial activity against Clostridioides difficile UNT-103-1 infected in Syrian hamster assessed as survival at 15 to 45 mg/kg, po administered once a daily for 5 days after 18 hrs post 10 mg/kg clindamycin treatment and measured upto 21 days
Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability
Cytotoxicity against golden hamster BSR cells
Toxicity in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes assessed as body weight loss at 50 mg/kg, po SID and administered for 10 days and measured twice weekly
Toxicity in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes assessed as gross pathological changes at 50 mg/kg, po SID and measured after 10 days
Volume of distribution in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes at 50 mg/kg, po SID and measured after 10 days by LC-MS/MS analysis
Clearance in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes at 50 mg/kg, po SID and measured after 10 days by LC-MS/MS analysis
AUC (0 to 24) in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes at 50 mg/kg, po SID and measured after 10 days by LC-MS/MS analysis
AUC (0 to 8) in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes at 50 mg/kg, po SID and measured after 10 days by LC-MS/MS analysis
Half life in golden hamster infected with Leishmania infantum MHOM/MA(BE)/67 amastigotes at 50 mg/kg, po SID and measured after 10 days by LC-MS/MS analysis
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