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Antiviral activity against JC polyomavirus infected in African green monkey G144 Vero cells assessed as reduction in late viral protein and viral capsid protein VP1 incubated for 72 hrs by branched DNA assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of helicase activity of JC polyomavirus LTAg (E264 to D628 residues) expressed in Escherichia coli using Cy5/BHQ3 dsDNA pre-incubated for 20 mins and measured after 120 to 180 mins by fluorescence based assay
Assay data:13 Active, 2 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antiviral activity against JC polyomavirus MAD-4 infected in grivet COS7 cells assessed as reduction in DNA copy number after 7 days by PCR analysis
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Antiviral activity against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in viral infectivity pre-incubated for 0.5 hrs with compound before viral infection for 72 hrs by flow cytometry
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against JC polyomavirus Mad4 infected in human SVG-A cells assessed as inhibition of viral replication after 3 days
Assay data:1 Active, 1 Tested
Antiviral activity against JC polyomavirus Mad1 infected in human PHFG cells assessed as inhibition of viral replication after 3 days
Antiviral activity against JC polyomavirus M1/SVEdelta infected in human PHFG cells assessed as inhibition of viral replication after 3 days
Antiviral activity against JC polyomavirus M1/SVEdelta infected in human SVG-A cells assessed as inhibition of viral replication after 3 days
Assay data:9 Active, 18 Tested
Inhibition of retrograde transport of JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in co-localization of viral capsid protein VP1 and ER protein PDI pre-incubated for 0.5 hrs with compound before viral infection for 1 hr followed by incubation with compound at 0.05 mM for 8 hrs by proximity ligation assay
Inhibition of retrograde transport of JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in co-localization of viral capsid protein VP1 and ER protein PDI pre-incubated for 0.5 hrs with compound before viral infection for 1 hr followed by incubation with compound at 0.1 mM for 8 hrs by proximity ligation assay
Potency index, ratio of IC50 for Retro-2(cycl) to IC50 for test compound against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as reduction in viral infectivity pre-incubated for 0.5 hrs with compound before viral infection for 72 hrs by flow cytometry
Assay data:1 Tested
SummaryPubMed Citation
Antiviral activity against JC polyomavirus Mad1-SVEdelta infected in SVG-A cells assessed as viral infectivity level pre-incubated for 0.5 hrs with 25 uM compound before viral infection for 72 hrs by flow cytometry relative to DMSO control
Assay data:38 Tested
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