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Antiviral activity against HIV assessed as viral growth inhibition
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against Human immunodeficiency virus
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity agianst HIV assessed as viral growth inhibition
Antiviral activity against HIV
Antiviral activity against HIV p24 assessed as extracellular antigen accumulation in primary macrophage at 25 uM
Assay data:1 Tested
SummaryPubMed Citation
Antiviral activity against HIV NL4-3 infected in MT-4 cells assessed as viral replication measured after 4 days by p24-ELISA
Assay data:4 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of HIV reverse transcriptase
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Substrate activity at HIV reverse transcriptase assessed as DNA elongation using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 15 mins and at 80 degreeC for 3 mins in presence of TTP by primer extension assay
Substrate activity at HIV reverse transcriptase assessed as DNA elongation using 5'-Cy3-CGTTG GTCCT GAAGG AGGAT AGG1T-3' as primer and 3'-GCAAC CAGGA CTTCC TCCTA TCCAA AGACA-5' as template incubated at 37 degree C for 15 mins and at 80 degreeC for 3 mins by primer extension assay
Antiviral activity against HIV infected in human PBMC assessed as inhibition of viral infection at MOI of 0.5 incubated for 48 hrs followed by removal of infected supernatant and subsequent addition of supernatant to human LC-5 cells expressing DsRed1 measured after 72 hrs by EASY-HIT assay
Antiviral activity against HIV infected in human HeLa cells expressing CD4-LTR-beta-gal assessed as inhibition of syncytia formation measured after 15 hrs by 5-bromo-4-chloro-3-indolyl-beta-D-galactoside staining based colorimetry assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against Human immunodeficiency virus pseudotyped with VSV-G envelope preincubated for 30 mins followed by viral infection for 48 hrs by luciferase assay
Assay data:5 Tested
Inhibition of HIV reverse transcriptase K103N mutant
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of wild-type HIV reverse transcriptase
Antiviral activity against cross-resistant HIV mutant
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibitory activity of compound against human immunodeficiency virus (HIV) was evaluated in vitro; Inactive
Assay data:9 Tested
The compound was tested for anti-HIV activity; Range = 5.0-15.0 uM
Assay data:1 Active, 1 Tested
Potency index, ratio of test compound IC50 to TXL IC50 for antiviral activity against human immunodeficiency virus expressed in HEK293T cells coexpressing firefly luciferase gene incubated for 48 hrs by Bright-Glo luciferase assay
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