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Supercoiling Assay from Article 10.1111/cbdd.12529: "Design and Biological Evaluation of Furan/Pyrrole/Thiophene-2-carboxamide Derivatives as Efficient DNA GyraseB Inhibitors of Staphylococcus aureus."
Assay data:9 Active, 1 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
ATPase Assay from US Patent US9040542: "Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Inhibition Assay from US Patent US11572337: "Antibacterial agents: arylalkylcarboxamido phloroglucinols"
Assay data:27 Active, 44 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Assay of Inhibition of Staphylococcus Aureus RNA Polymerase from US Patent US10800725: "Arylpropionyl-triketone antibacterial agents"
Assay data:14 Active, 2 Activity ≤ 1 µM, 20 Tested
Inhibition Kinetics Assay from Article 10.1074/jbc.M113.532804: "Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor."
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Fluorescence Titration Assay from Article 10.1074/jbc.M112.442335: "The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype."
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
UV-Visible Titration Assay from Article 10.1074/jbc.M112.442335: "The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
DHFR Inhibition Assay from Article 10.1016/j.chembiol.2016.11.007: "MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates."
Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested
Colorimetric Malachite Green Assay from Article 10.1021/acschembio.6b00510: "Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis."
Assay data:14 Tested
SummaryPubMed CitationRelated BioAssays by Target
In vitro Enzyme Inhibition Assay from Article 10.1111/cbdd.12793: "Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation."
Assay data:4 Active, 1 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
GTPase Activity Assay from US Patent US9169182: "Chrysophaentin analogs that inhibit FtsZ protein"
Assay data:2 Tested
SummaryRelated BioAssays by Target
GyraseB Assay from Article 10.1111/cbdd.12529: "Design and Biological Evaluation of Furan/Pyrrole/Thiophene-2-carboxamide Derivatives as Efficient DNA GyraseB Inhibitors of Staphylococcus aureus."
Assay data:4 Active, 2 Activity ≤ 1 µM, 26 Tested
Fluorescence Based Assay from US Patent US9051321: "Heterocyclic acrylamides and their use as pharmaceuticals"
Assay data:26 Active, 17 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibitor Assay from US Patent US8927520: "Antibacterial compounds"
Assay data:1 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US8853228: "Heterocyclic analogs of propargyl-linked inhibitors of dihydrofolate reductase"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Fluorescence Based Assay from US Patent US8846711: "Heterocyclic acrylamides and their use as pharmaceuticals"
Assay data:27 Active, 18 Activity ≤ 1 µM, 28 Tested
Inhibition Assay from US Patent US8835445: "Dihydrofolate reductase inhibitors"
Assay data:40 Active, 31 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested
Inhibition Assay from US Patent US8623865: "Acylpiperazinones and their use as pharmaceuticals"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Thermal Shift Assay from Article 10.1021/bi400413c: "Rational Optimization of Drug-Target Residence Time: Insights from Inhibitor Binding to the Staphylococcus aureus FabI Enzyme-Product Complex."
Assay data:20 Active, 16 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
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