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Cellular Assay-Influenza Virus Replication PR8 and X31 in Calu-3 Human Bronchial Epithelial Cells from US Patent US10988505: "Matriptase inhibitors and uses thereof"
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Influenza A virus H3N2 A/X-31 hemagglutinin 3 E572K mutant expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic analysis
Assay data:1 Active, 7 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of influenza H3N2 A/X-31 hemagglutinin 3 expressed in HeLa cells assessed as polykaryon formation preincubated for 15 mins and further incubated for 15 mins with acidic buffer containing compounds at pH 5.2 by giemsa staining based microscopic analysis
Assay data:6 Active, 1 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of influenza virus A/WSN/1933 (H1N1) neuraminidase using MUNANA as substrate preincubated for 10 mins followed by substrate addition and measured for 15 mins by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Influenza virus A/X-31 RNA dependent RNA polymerase using ApG primer [adenyl (3'-5') guanosine] and [8-3H]GTP after 1 hr by filter-based assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Antiviral activity against Influenza virus A/X-31 infected in HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay
Assay data:6 Active, 1 Activity ≤ 1 µM, 13 Tested
Antiviral activity against Influenza virus A/X-31 infected in HGPRT deficient 6-thioguanine-resistant MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis
Assay data:6 Active, 13 Tested
Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by formazan-based MTS assay
Antiviral activity against Influenza virus A/X-31 infected in MDCK cells assessed as reduction in viral replication at 3 days post infection by microscopic analysis
Assay data:7 Active, 13 Tested
Inhibition of recombinant influenza A virus A/X-31 N-terminal 6His tagged-PA endonuclease (1 to 217 residues) expressed in Escherichia coli BL21-CodonPlus cells after 1 hr using single stranded circular DNA plasmid M13mp18 as substrate by ethidium bromide staining based agarose gel electrophoresis
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of recombinant influenza A virus A/X-31 N-terminal PA endonuclease (1 to 217 residues) after 2 hrs using single stranded circular DNA plasmid M13mp18 as substrate by ethidium bromide staining based agarose gel electrophoresis
Assay data:1 Active, 1 Tested
Inhibition of recombinant influenza A virus A/X-31 N-terminal 6His tagged-PA endonuclease (1 to 217 residues) expressed in Escherichia coli BL21-CodonPlus cells after 2 hrs using single stranded circular DNA plasmid M13mp18 as substrate by ethidium bromide staining based agarose gel electrophoresis
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant Influenza A virus (A/X-31(H3N2)) N-terminal 6xHis-tagged PA-Nter (1 to 217 residues) expressed in Escherichia coli BL21-CodonPlus cells using M13mp18 as substrate after 1 hr by ethidium bromide staining-based agarose gel electrophoresis
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant Influenza A/X-31 virus PA infected in HEK293T cells after 2 hrs by vRNP reconstitution assay
Assay data:7 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant Influenza A/X-31 virus PA (N-terminal amino acid residue 1-217) transfected in Escherichia coli assessed as endonucleolytic digestion using single-stranded circular DNA plasmid M13mp18 after 2 hrs by ethidium bromide staining based agarose gel electrophoresis
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of recombinant Influenza virus A/X-31 N-terminal RdRp PA subunit (1 to 217) expressed in Escherichia coli using single-stranded circular DNA plasmid M13mp18 as substrate after 2 hrs by agarose gel electrophoresis
Assay data:3 Active, 2 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhbition of Influenza A virus (A/X-31(H3N2) hemagglutinin binding to 2 hrs compound pre-incubated MDCK cells assessed as reduction in viral RNA measured after 1 hr by RT-qPCR analysis
Assay data:2 Active, 2 Tested
Antiviral activity against Influenza A virus (A/X-31(H3N2)) infected in MDCK cells assessed as virus-induced cytopathic effect after 3 days by microscopic analysis
Assay data:3 Active, 16 Tested
Antiviral activity against Influenza A virus (A/X-31(H3N2)) infected in MDCK cells assessed as virus-induced cytopathic effect after 3 days by MTS assay
Assay data:4 Active, 16 Tested
Inhibition of hemagglutininin in Influenza A virus (A/X-31(H3N2)) infected in chicken red blood cells assessed as inhibition of hemolysis preincubated for 1 hr prior to addition of red blood cells measured at pH 5.0 by spectrophotometric analysis
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