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Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS3 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay
Assay data:1 Active, 8 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS2 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay
Assay data:1 Active, 38 Tested
Inhibition of Kaposi's sarcoma herpesvirus C-terminal His-tagged oligomerization deficient LANA DBD (1008 to 1146 residues) K1055E/K1138S/K1140D/K1141D/R1039Q/R1040Q/A1121E/K1109A/D1110A mutant expressed in Escherichia coli BL21(DE3) assessed as inhibition of LANA interaction with fluorescently-labelled viral DNA LBS1 probe preincubated with LANA-DBD for 60 mins followed by addition of DNA probe and measured after 90 mins by flourescence polarization assay
Binding affinity to human herpesvirus human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) by microscale thermophoresis assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of fluorescent labelled LBS3 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 60 mins followed by fluorescent labelled LBS2 addition and measured after 90 mins by fluorescence polarization assay
Assay data:6 Tested
Inhibition of fluorescent labelled LBS1 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 60 mins followed by fluorescent labelled LBS2 addition and measured after 90 mins by fluorescence polarization assay
Inhibition of fluorescent labelled LBS2 DNA binding to human herpesvirus 8 C-terminal His-tagged LANA oligomerization deficient mutant DBD (1008 to 1146 residues) expressed in Escherichia coli BL21 (DE3) preincubated for 60 mins followed by fluorescent labelled LBS2 addition and measured after 90 mins by fluorescence polarization assay
Assay data:25 Tested
Antiviral activity against Kaposi's sarcoma-associated herpesvirus infected in African green monkey Vero cells exposed to supernatant from 48 hrs compound treated human iSLK.219 cells infected with KSHV by GFP based microscopy
Antiviral activity against HHV-8 infected in human BCBL1 cells assessed as reduction in viral DNA after 7 days by qPCR analysis
Assay data:1 Active, 34 Tested
Antiviral activity against Human herpesvirus 8 infected in human BCBL1 cells assessed as decrease in viral DNA accumulation after 7 days
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against Human herpesvirus 8 infected in human BC-3 cells assessed as inhibition of virus DNA replication after 12 days by quantitative real time PCR
SummaryPubMed Citation
Inhibition of KSHV protease M197L mutant by fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of KSHV wild type protease by fluorescence assay
Inhibition of KSHV protease by fluorogenic activity assay
Assay data:2 Active, 3 Tested
Activity at KSHV protease at 10 uM
Activity at KSHV protease at 7 uM
Activity at KSHV protease at 5 uM
Activity at KSHV protease at 3 uM
Activity at KSHV protease at 1 uM
Cytotoxicity against Kaposi's sarcoma-associated herpesvirus infected BC2 cells after 120 hrs by MTT assay
Assay data:6 Active, 1 Activity ≤ 1 µM, 11 Tested
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