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Plasma concentration on marmosets at 7 mg/kg, sc measured after 105 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Plasma concentration on marmosets at 7 mg/kg, sc measured after 60 mins
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of 17beta-HSD3 in marmoset testes homogenate
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Partition co-efficient, Kp in marmosets liver assessed per gram of tissue at 3 mg/kg, po administered as single dose measured at 1 hr
Assay data:2 Tested
SummaryPubMed Citation
Bioavailability determined after oral administration in marmoset
Assay data:1 Tested
Reduction in total cholesterol level in marmosets at 30 mg/kg/day, po for 7 days
Assay data:4 Tested
Reduction in non-HDL cholesterol level in marmosets at 30 mg/kg/day, po for 7 days
Reduction in HDL cholesterol level in marmosets at 30 mg/kg/day, po for 7 days
Reduction in triglyceride level in marmosets at 30 mg/kg/day, po for 7 days
Drug uptake in marmosets liver assessed per gram of tissue at 3 mg/kg, po administered as single dose measured at 1 hr
Antimigraine activity in marmosets assessed as inhibition of human alphaCGRP-induced increase in facial blood flow at 7 mg/kg, sc measured after 105 mins by laser Doppler flowmetry
Antimigraine activity in marmosets assessed as inhibition of human alphaCGRP-induced increase in facial blood flow at 7 mg/kg, sc measured after 60 mins by laser Doppler flowmetry
Antimigraine activity in marmosets assessed as inhibition of alphaCGRP-induced increase in facial blood flow at 10 mg/kg, po by laser Doppler flowmetry
Lipid lowering effect in marmosets assessed as reduction in plasma triglyceride level at 100 mg/kg, po administered once daily for 7 days
Assay data:6 Tested
Lipid lowering effect in marmosets assessed as reduction in plasma non HDL-cholesterol level at 100 mg/kg, po administered once daily for 7 days
Lipid lowering effect in marmosets assessed as reduction in plasma HDL-cholesterol level at 100 mg/kg, po administered once daily for 7 days
Lipid lowering effect in marmosets assessed as reduction in plasma total cholesterol level at 100 mg/kg, po administered once daily for 7 days
Reduction in serum triglyceride levels in marmosets at 100 mg/kg/day, po for 5 days
Reduction in serum HDL cholesterol level in marmosets at 100 mg/kg/day, po for 5 days
Reduction in serum non-HDL cholesterol level in marmosets at 100 mg/kg/day, po for 5 days
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