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FP-based equilibrium competition assay from US Patent US11312722: "Hsp90 inhibitors and uses thereof"
Assay data:111 Active, 100 Activity ≤ 1 µM, 113 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
AlphaScreen Assay from Article 10.1021/cb400452z: "PIF-pocket as a target for C. albicans Pkh selective inhibitors."
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Protein Kinase Activity Assay from Article 10.1021/cb400452z: "PIF-pocket as a target for C. albicans Pkh selective inhibitors."
Assay data:1 Tested
Enzyme Assay from Article 10.1006/bioo.1997.1077: "Investigation of Mechanism of Nitrogen Transfer in Glucosamine 6-Phosphate Synthase with the Use of Transition State Analogs"
Assay data:15 Tested
Summary
Inhibition Assay from Article 10.1016/S1074-5521(02)00240-5: "Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors."
Assay data:6 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
CA Inhibition Assay from Article 10.1016/j.bmc.2009.05.002: "Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides."
Assay data:37 Active, 32 Activity ≤ 1 µM, 37 Tested
Enzyme Inhibition Assay from Article 10.1021/jm0101444: "X-Ray crystal structures of Candida albicans dihydrofolate reductase: high resolution ternary complexes in which the dihydronicotinamide moiety of NADPH is displaced by an inhibitor."
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of Candida albicans CYP51 assessed as unknown sterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Candida albicans CYP51 assessed as 14alpha-methylergosta-8,24(28)-dien3beta-6alpha-diol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Inhibition of Candida albicans CYP51 assessed as eburicol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Inhibition of Candida albicans CYP51 assessed as ergosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Inhibition of Candida albicans CYP51 assessed as lanosterol level at 0.25 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Inhibition of Candida albicans CYP51 assessed as unknown sterol level at 0.015 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Assay data:2 Tested
Inhibition of Candida albicans CYP51 assessed as 14alpha-methylergosta-8,24(28)-dien3beta-6alpha-diol level at 0.015 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Inhibition of Candida albicans CYP51 assessed as eburicol level at 0.015 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Inhibition of Candida albicans CYP51 assessed as ergosterol level at 0.015 ug/ml measured after 18 hrs by GC-MS analysis relative to control
Antifungal activity against fluconazole and itraconazole resistant Candida albicans 17# assessed as inhibition of fungal growth by NCCLS protocol based method
Assay data:9 Tested
SummaryPubMed Citation
Antifungal activity against fluconazole resistant Candida albicans CaR assessed as inhibition of fungal growth by NCCLS protocol based method
Antifungal activity against Candida parapsilosis GIM2.190 assessed as inhibition of fungal growth by NCCLS protocol based method
Assay data:27 Tested
Antifungal activity against Candida albicans GIM2.194 assessed as inhibition of fungal growth by NCCLS protocol based method
Assay data:35 Tested
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