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Inhibition of Beta-Lactamase Enzymes from US Patent US10800778: "Beta-lactamase inhibitor compounds"
Assay data:39 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 40 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Test for beta-lactamase Inhibitory Activity from US Patent US10544146: "Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Kinetic Assay from Article 10.1074/jbc.M113.533562: "The different inhibition mechanisms of OXA-1 and OXA-24 -lactamases are determined by the stability of active site carboxylated lysine."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cell Free Inhibition Assay from US Patent US9120808: "Substituted clavulanic acid"
Assay data:38 Active, 3 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 42 Tested
Inhibition Assay from Article 10.1016/S1074-5521(01)00034-5: "Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase."
Assay data:33 Active, 17 Activity ≤ 1 µM, 41 Tested
Beta-lactamase CTX-M Inhibition Assay from Article 10.1038/nchembio.155: "Molecular docking and ligand specificity in fragment-based inhibitor discovery."
Assay data:14 Tested
SummaryPubMed CitationRelated BioAssays by Depositor
Inhibition of his tagged Escherichia coli K12 MurA C115D mutant using UDP-N-acetylglucosamine as substrate in presence of DTT and PEP by microplate reader analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Uncompetitive inhibition of wild type his tagged Escherichia coli K12 MurA at 2.23 to 3.34 uM using varying concentration of UDP-N-acetylglucosamine as substrate measured after 5 to 30 mins by malachite green assay
Inhibition of his tagged Escherichia coli K12 MurA C115D mutant at 2 uM using UDP-N-acetylglucosamine as substrate in presence of DTT, PEP and fosfomycin by microplate reader analysis relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of wild type his tagged Escherichia coli K12 MurA C115D mutant at 2 uM using UDP-N-acetylglucosamine as substrate in presence of DTT and PEP by microplate reader analysis relative to control
Assay data:2 Tested
Inhibition of wild type his tagged Escherichia coli K12 MurA at 2 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins in presence of fosfomycin by malachite green based microplate reader analysis relative to control
Inhibition of wild type his tagged Escherichia coli K12 MurA at 2 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins by malachite green based microplate reader analysis relative to control
Inhibition of wild type his tagged Escherichia coli K12 MurA at 0.2 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 15 mins prior to compound addition for 15 mins followed by DTT and PEP addition by dilution assay
Assay data:1 Active, 2 Tested
Stability in Escherichia coli delta tolC bacterial lysate assessed as half life by HPLC-MS analysis
SummaryPubMed Citation
Stability in Escherichia coli delta tolC bacterial lysate assessed as degradation measured after 4 hrs by HPLC-MS analysis
Antibacterial activity against Escherichia coli harboring delta tolC efflux defective mutant assessed as inhibition of bacterial growth incubated for 16 hrs in presence of 6 ug/ml PMBN by microplate reader analysis (Rvb = >40 microM)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antibacterial activity against Escherichia coli harboring delta tolC efflux defective mutant assessed as inhibition of bacterial growth incubated for 16 hrs by microplate reader analysis
Inhibition of wild type his tagged Escherichia coli K12 MurB at 20 uM using UNAGEP as substrate preincubated for 15 mins followed by NADPH addition and measured for 2 mins by microplate reader analysis relative to control
Inhibition of wild type his tagged Escherichia coli K12 MurA using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins by malachite green based microplate reader analysis
Assay data:12 Active, 41 Tested
Inhibition of wild type his tagged Escherichia coli K12 MurA at 20 uM using UDP-N-acetylglucosamine as substrate preincubated with substrate for 30 mins prior to compound addition for 15 mins followed by DTT and PEP addition and measured after 30 mins by malachite green based microplate reader analysis relative to control
Assay data:47 Tested
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