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Inhibition Assay from Article 10.3109/14756369809035823: "Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase."
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Crithidia fasciculata nucleoside hydrolase
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of Crithidia fasciculata inosine-uridine nucleoside hydrolase expressed in Escherichia coli using p-nitrophenyl beta-D-ribofuranoside as substrate by xanthine oxidase coupled enzyme assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DHFR in Crithidia oncopelti using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition by spectrofluorometric analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antitrypanosomal activity against Crithidia fasciculata
Assay data:6 Active, 5 Activity ≤ 1 µM, 8 Tested
Inhibition of Crithidia fasciculata trypanothione reductase-substrate complex
Assay data:1 Tested
Inhibition of Crithidia fasciculata free trypanothione reductase
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Effect of dose dependent inhibition of TOPO II-catalyzed kDNA decatenation in vitro
Assay data:3 Active, 9 Tested
Inhibitory activity of compound against inosine-uridine nucleoside hydrolase (IU-NH) from crithidia fasciculata
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
Inhibitory constant against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata
Assay data:3 Active, 8 Tested
Tested against glutathionylspermidine synthetase (GspS) in Crithidia fasciculata
Assay data:2 Active, 15 Tested
Inhibition of Glutathionylspermidine synthetase. Values from different publications.
Inhibition of Glutathionylspermidine synthetase from Escherichia coli, value taken from literature
Inhibition of Glutathionylspermidine synthetase
Michaelis-Menten constant at the concentration of < 0.4 mM
Compound was tested for substrate activity (Apparent Km) towards the enzyme Glutathionylspermidine Synthetase wild-type enzyme and compared with 0.5 mM GSH
Inhibitory constant against amidase free Glutathionylspermidine Synthetase mutant (C79A)
Inhibition constant was evaluated against enzyme Glutathionylspermidine Synthetase wild-type enzyme
Assay data:2 Tested
Inhibitory activity against amidase free Glutathionylspermidine Synthetase mutant (C79A)
Assay data:1 Active, 2 Tested
Concentration required for the inhibition of enzyme Glutathionylspermidine Synthetase wild-type enzyme
Assay data:1 Active, 5 Tested
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