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Enzyme Inhibition Assay from US Patent US9353089: "Compositions and methods for the treatment of malaria"
Assay data:80 Active, 76 Activity ≤ 1 µM, 82 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Growth Inhibition Assay from US Patent US9200020: "6-oxopurine phosphoribosyltransferase inhibitors"
Assay data:10 Active, 6 Activity ≤ 1 µM, 13 Tested
Inhibiton Assay from US Patent US9238653: "Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase"
Assay data:53 Active, 44 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
TBD from US Patent US11365202: "Antimalarial compounds, process for preparation and their use for drug resistant malaria"
Assay data:6 Active, 10 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Efficacy of ELQ-337 In Vitro from US Patent US10584098: "Quinolone-3-diarylethers"
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Fluorescence Resonance Energy Transfer (FRET)-Based Assay from Article 10.3109/14756360903508430: "Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors."
Assay data:6 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
DHODH Biochemical Assay from Article 10.1074/jbc.M114.558353: "In vitro resistance selections for Plasmodium falciparum dihydroorotate dehydrogenase inhibitors give mutants with multiple point mutations in the drug-binding site and altered growth."
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Spectrophotometric Assay from US Patent US9200020: "6-oxopurine phosphoribosyltransferase inhibitors"
Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested
Inhbition Assay from Article 10.1016/j.chembiol.2012.04.012: "Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase."
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Parasite Proliferation Assay from Article 10.1038/nchembio.87: "Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility."
Assay data:12 Active, 10 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Scintillation Proximity Assay from Article 10.1038/nchembio.87: "Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility."
Assay data:14 Active, 10 Activity ≤ 1 µM, 14 Tested
Enzyme Inhibition Assay from Article 10.1016/j.bmc.2008.08.012: "Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors."
Assay data:7 Active, 1 Activity ≤ 1 µM, 11 Tested
DHODH Inhibition Assay from Article 10.1021/jm800963t: "Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases."
Assay data:17 Active, 15 Activity ≤ 1 µM, 17 Tested
DHODH Inhibition Assay from Article 10.1021/jm801343r: "Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice."
Assay data:25 Active, 9 Activity ≤ 1 µM, 43 Tested
DHODH Inhibition Assay from Article 10.1021/jm8001026: "Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum."
Assay data:10 Active, 6 Activity ≤ 1 µM, 14 Tested
Lactate Dehydrogenase Inhibition Assay from Article 10.1074/jbc.M402433200: "Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity."
Assay data:3 Active, 3 Activity ≤ 1 µM, 26 Tested
Lactate Dehydrogenase Inhibition Assay from Article 10.1021/jm070336k: "Design, synthesis, and biological evaluation of Plasmodium falciparum lactate dehydrogenase inhibitors."
Assay data:5 Active, 2 Activity ≤ 1 µM, 10 Tested
Antimalarial Testing In Vitro (IC50) and Measurement of Inhibition Constant (Ki) from Article 10.1038/nsb921: "Insights into antifolate resistance from malarial DHFR-TS structures."
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
DHODH Inhibition Assay from Article 10.1016/j.bmcl.2005.09.045: "The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase."
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
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