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Antischistosomal activity against Schistosoma mansoni infected in NMRI mouse assessed as reduction in worm burden at 400 mg/kg, po administered as single dose
Assay data:1 Tested
SummaryPubMed Citation
Antischistosomal activity against Schistosoma mansoni infected in NMRI mouse assessed as reduction in worm burden at 100 mg/kg, po administered 4 times every 4 hrs
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as inhibition of oviposition at 0.0024 to 10 uM measured after 72 hrs
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antischistosomal activity against Schistosoma mansoni Puerto-Rican schistosomula assessed as inhibition of parasite motility at 50 uM measured after 72 hrs
Assay data:1 Active, 1 Tested
Antischistosomal activity against Schistosoma mansoni Puerto-Rican schistosomula assessed as phenotypic changes at 50 uM measured after 72 hrs
Antischistosomal activity against juvenile stage of Schistosoma mansoni assessed as increased granularity with reduced movement at 0.156 uM measured after 72 hrs by PI staining based analysis
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as inhibition of in vitro laid eggs production at 6.25 uM measured after 72 hrs
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as cessation of worm motility at 6.25 uM measured after 72 hrs
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as absence of body/gut movement, plate detachment and severe damage to the tegument at 25 to 50 uM measured after 72 hrs
Antischistosomal activity against Schistosoma mansoni assessed as inhibition of miracidial to sporocyst transformation measured after 48 hrs
Antischistosomal activity against Schistosoma mansoni assessed as parasite death at 10 to 50 uM measured after 48 hrs
Antischistosomal activity against juvenile stage of Schistosoma mansoni measured after 72 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antischistosomal activity against Schistosoma mansoni assessed as inhibition of miracidial to sporocyst transformation at 5 uM measured after 48 hrs
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as inhibition of oviposition at 0.0095 to 10 uM measured after 72 hrs
Assay data:2 Active, 2 Tested
Antischistosomal activity against Schistosoma mansoni assessed as inhibition of miracidial to sporocyst transformation at 0.5 to 2 uM measured after 48 hrs
Antischistosomal activity against juvenile stage of Schistosoma mansoni assessed as parasite death at 1.25 to 10 uM measured after 72 hrs by PI staining based analysis
Antischistosomal activity against juvenile stage of Schistosoma mansoni assessed as parasite death at 0.156 uM measured after 72 hrs by PI staining based analysis
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as inhibition of in vitro laid eggs production at 12.5 uM measured after 72 hrs
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as inhibition of parasite motility measured after 72 hrs
Assay data:16 Active, 16 Activity ≤ 1 µM, 26 Tested
Antischistosomal activity against adult stage of Schistosoma mansoni assessed as cessation of worm motility at 3.15 uM measured after 72 hrs
Assay data:3 Tested
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