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Tested in vitro for the biological efficacy using Caenorhabditis elegans binding assay; no data.
Assay data:4 Tested
Summary
In vivo inhibition of KRAS signaling in Caenorhabditis elegans lin-1 L1 harboring let60 G13D mutant assessed as reduction in multi-vulva phenotype measured after 4 to 5 days culturing in buffer containing Escherichia coli OP50 by DIC/Nomarski microscopic analysis
SummaryPubMed Citation
Nematocidal activity against Caenorhabditis elegans
Assay data:1 Active, 8 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of GST-tagged Caenorhabditis elegans CRN-4 exonuclease activity expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by [gamma-32P]ATP labelled 11-nucleotide ssRNA substrate addition for 30 mins by PAGE based autoradiography
Assay data:2 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MANT-uracil binding to Caenorhabditis elegans CRBN (delta 1 to 15) by Cheng-Prusoff equation analysis
Assay data:1 Active, 4 Tested
Inhibition of MANT-uracil binding to Caenorhabditis elegans CRBN (delta 1 to 15) by FRET assay
Binding affinity to Caenorhabditis elegans CRBN (delta 1 to 15) by FRET assay
Assay data:1 Tested
Inhibition of hatch of eggs newly spawned by adult Caenorhabditis elegans measured on day 3
Assay data:20 Tested
Growth inhibition of adult Caenorhabditis elegans measured on day 3 by microscopy
Transactivation of Caenorhabditis elegans DAF-12 receptor LBD transfected in HEK293 cells co-expressing Gal4-DBD after 20 hrs by luciferase reporter gene assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Induction of dauer formation in wild type Caenorhabditis elegans Bristol N12 at 20 degC
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Induction of dauer formation in wild type Caenorhabditis elegans Bristol N12 at 25 degC
Induction of oocyte production in Caenorhabditis elegans Bristol isolate N2 with puf-1; lip-1 double mutant
Assay data:1 Active, 1 Tested
Protection against mutant PABPN1-induced toxicity in transgenic Caenorhabditis elegans coexpressing nuclear GFP and PABPN1-A13 assessed as inhibition of deffective worm motility
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of Caenorhabditis elegans CAH-4b by stopped flow CO2 hydration assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of Caenorhabditis elegans carbonic anhydrase 4b by CO2 hydration assay
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Cell death rescue of ASH neuronal cells in Caenorhabditis elegans Huntington's disease model
Assay data:1 Active, 3 Tested
Toxicity in Caenorhabditis elegans Huntington's disease model
Rate of deamination was determined against deaminase purified from human acute myeloblastic leukemia cells
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Compound was evaluated for the binding affinity for Caenorhabditis elegans avermectin using Caenorhabditis elegans membrane homogenates using [3H]IVM as radioligand
Assay data:7 Active, 6 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
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