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Antiparasitic activity against third stage larvae of Onchocerca volvulus assessed as parasite growth inhibition incubated for 6 days by inverted microscopy
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
AntiOnchocerca activity O. volvulus L3 Molting assay: inhibition at 10 uM (%)
Assay data:8 Tested
Summary
AntiOnchocerca activity O. volvulus L3 Molting assay: IC50 (uM)
Assay data:3 Active, 3 Tested
SummaryCompounds, Active
Inhibition of Onchocerca volvulus chitinase by fluorescence based assay
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Competitive inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone measured for 10 mins by Dixon plot analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone measured for 10 mins by fluorescence assay
Assay data:8 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate after 10 mins by microplate reader analysis
Assay data:20 Active, 9 Activity ≤ 1 µM, 20 Tested
Inhibition of Onchocerca volvulus L3 larvae chitinase using 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as a profluorescent substrate after 10 mins by fluorometric analysis
Assay data:9 Active, 4 Activity ≤ 1 µM, 10 Tested
The compound was tested for it's inhibitory activity against Onchocerca volvulus Glutathione S-transferase 2
Assay data:2 Active, 11 Tested
Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone at 5 uM measured for 10 mins by fluorescence assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of L3 larval stage of Onchocerca volvulus chitinase using 4-methylumbelliferyl-N-N'-N''-beta-chitotrioside as substrate assessed as release of 4-methylumbelliferone at 10 uM measured for 10 mins by fluorescence assay
Assay data:15 Tested
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 2.5 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC and 2.5 uM protonophore CCCP
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 1 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC and 1 uM protonophore CCCP
Assay data:1 Tested
SummaryPubMed Citation
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 0.5 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC and 0.5 uM protonophore CCCP
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 100 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 10 uM for 24 hrs measured until 6 days by using inverted microscopic analysis in presence of PBMC
Assay data:6 Active, 7 Tested
Inhibition of Onchocerca volvulus L3 larvae chitinase using 20 uM 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as substrate at 10 uM after 10 mins by microplate reader analysis
Assay data:5 Active, 5 Tested
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 50 uM after 6 days by using inverted microscopic analysis
Assay data:2 Tested
Antiparasitic activity against Onchocerca volvulus assessed as inhibition of L3 to L4 larval molting at 25 uM after 6 days by using inverted microscopic analysis
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