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Antibacterial activity against Yersinia pseudotuberculosis
Assay data:23 Tested
Summary
Steady-State Kinetics from Article 10.1021/acs.biochem.5b01301: "Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Inhibition Kinetics from Article 10.1021/acs.biochem.5b01301: "Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase."
Assay data:20 Active, 9 Activity ≤ 1 µM, 22 Tested
FabZ Inhibition Assay from Article 10.1021/acs.biochem.5b00832: " -Hydroxyacyl-acyl Carrier Protein Dehydratase (FabZ) from Francisella tularensis and Yersinia pestis: Structure Determination, Enzymatic Characterization, and Cross-Inhibition Studies."
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Binding affinity towards biotinylated His6-tagged Yersinia pseudotuberculosis CsrA measured by Microscale thermophoresis assay (MST)
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of 5'-UUCACGGAGAA[flc] mRNA binding to biotinylated His6-tagged Yersinia pseudotuberculosis CsrA measured in presence of 5 mM DTT by fluorescence polarization assay
Inhibition of 5'-UUCACGGAGAA[flc] mRNA binding to biotinylated His6-tagged Yersinia pseudotuberculosis CsrA measured by fluorescence polarization assay
Assay data:1 Active, 18 Tested
Antibacterial activity against Yersinia pseudotuberculosis ATCC 6904 assessed as bacterial growth inhibition incubated for 18 to 20 hrs by broth microdilution method
Assay data:1 Active, 3 Tested
Antimicrobial activity against Yersinia pseudotuberculosis YPIII PIB102-Elux at 364 uM by spectrophotometry
Assay data:3 Tested
Inhibition of YopH in Yersinia pseudotuberculosis YPIII PIB102-Elux using p-nitrophenyl phosphate as substrate measured after 3 hrs 15 mins by phosphatase enzyme assay
Assay data:3 Active, 4 Tested
Inhibition of YopE in Yersinia pseudotuberculosis YPIII PIB102-Elux measured after 3 hrs 15 mins by luminescent reporter-gene assay
Inhibition of T3SS-mediated LcrQ secretion in Yersinia pseudotuberculosis assessed as yopE promoter-luciferase gene expression by luciferase reporter gene assay
Assay data:4 Tested
Inhibition of type 3 secretion in Yersinia pseudotuberculosis by reporter gene assay
Inhibition of Yersinia pseudotuberculosis YopH
SummaryPubMed CitationRelated BioAssays by Target
Antibacterial activity against Yersinia pseudotuberculosis YPIII after 18 to 20 hrs by microbroth dilution method
Assay data:13 Active, 16 Tested
Assay data:2 Active, 3 Tested
Antimicrobial activity against Yersinia pseudotuberculosis YP3 after 18 to 20 hrs by micro-broth dilution method
Inhibitory activity against Yersinia pseudotuberculosis ATCC 6902
Assay data:9 Tested
Inhibition of Yersinia pseudotuberculosis serotype 3 T3SS assessed as reduction in YopD protein expression at > 13 uM preincubated for 1 hr at 26 degC and subsequently incubated for 3 hrs at 37 degC by Western blot analysis relative to control
Inhibition of Yersinia pseudotuberculosis serotype 3 T3SS assessed as reduction in YopD protein secretion at > 13 uM preincubated for 1 hr at 26 degC and subsequently incubated for 3 hrs at 37 degC by Western blot analysis relative to control
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