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Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 3 mg/kg, sc measured after 15 to 105 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Total plasma concentration in human CGRPalpha-induced migraine marmoset model at 7 mg/kg, sc measured after 15 to 105 mins
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
AUC (0-96 or 0-168h) of total radioactivity following single intravenous administration of [14C] aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
Assay data:1 Tested
Summary
AUC (0-96 or 0-168h) of unlabeled aliskiren hemifumarate following single intravenous administration of aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
AUC (0-96 or 0-168h) of total radioactivity following single oral administration of [14C] aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
AUC (0-96 or 0-168h) of unlabeled aliskiren hemifumarate following single oral administration of aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 100 mg.Kg-1 level studied on day 14 in female Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 50 mg.Kg-1 level studied on day 14 in female Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 10 mg.Kg-1 level studied on day 14 in female Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 100 mg.Kg-1 level studied on day 14 in male Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 50 mg.Kg-1 level studied on day 14 in male Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 10 mg.Kg-1 level studied on day 144 in male Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 100 mg.Kg-1 level studied on day 1 in female Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 50 mg.Kg-1 level studied on day 1 in female Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 10 mg.Kg-1 level studied on day 1 in female Callithrix jacchus
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 100 mg.Kg-1 level studied on day 1 in male Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 50 mg.Kg-1 level studied on day 1 in male Callithrix jacchus
Cmax of aliskiren hemifumarate following 2 week oral dosing of aliskiren hemifumarate at 10 mg.Kg-1 level studied on day 1 in male Callithrix jacchus
Plasma concentration in marmoset at 0.03 mg/kg, sc measured 15 to 105 mins post-dose
Plasma concentration in marmoset at 0.03 g/kg, sc after 15 mins
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