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In vitro renin inhibitory effect was evaluated for plasma renin activity (PRA) of marmoset plasma renin, Expressed as IC50
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset gut
Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset adrenal
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 50 mg/kg on day 7
Assay data:1 Tested
SummaryPubMed Citation
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 50 mg/kg on day 3
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 50 mg/kg on day 2
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 30 mg/kg on day 7
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 30 mg/kg on day 3
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 30 mg/kg on day 2
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 16.7 mg/kg on day 3
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 16.7 mg/kg on day 2
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 10 mg/kg on day 7
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 10 mg/kg on day 3
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose 10 mg/kg on day 2
Effect on % of cholesterol reduction measured on serum cholesterol level in marmosets after single iv dose (3 times a day for 3 days) 16.7 mg/kg on day 7
Compound was tested on serum cholesterol levels in marmosets after 7 days at intravenous 0.11 (mg/kg) dose in 6 animals
Compound was tested on serum cholesterol levels in marmosets after 7 days at 1(mg/kg/day) intravenous administration in 8 animals
Compound was tested on serum cholesterol levels in marmosets after 7 days at 1(mg/kg/day) intravenous administration in 6 animals
Assay data:3 Tested
Compound was tested on serum cholesterol levels in marmosets after 3 days at intravenous 0.33 (mg/kg) dose in 6 animals
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