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Inhibition of pig brain tubulin polymerization at 6 uM by spectrophotometer analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of pig brain tubulin polymerization at 12.5 uM by spectrophotometer analysis relative to control
Assay data:1 Tested
Inhibition of pig brain tubulin polymerization at 6 uM by spectrophotometer analysis relative to control
Inhibition of pig brain tubulin polymerization at 3 uM by spectrophotometer analysis relative to control
Inhibition of pig brain tubulin polymerization by spectrophotometeric analysis
Assay data:5 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Apparent oral clearance in Gottingen minipig at 20 mg/kg measured upto 24 hrs by HPLC-MS method
Assay data:3 Tested
SummaryPubMed Citation
AUC (0 to t) in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Cmax in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Half life in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Clearance in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
AUC (0 to t) in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Cmax in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Half life in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Protein binding in minipig plasma assessed as unbound fraction
Cmax in Yucatan minipig at 300 mg/kg, po using radiolabeled compound administered for 3 weeks
Cmax in Yucatan minipig at 125 mg/kg, po using radiolabeled compound administered for 3 weeks
Cmax in Yucatan minipig at 50 mg/kg, po using radiolabeled compound administered for 3 weeks
Cmax in Yucatan minipig at 20 mg/kg, po using radiolabeled compound administered for 3 weeks
Cmax in Gottingen minipig at 10 mg/kg, po using radiolabeled compound by quantitative whole-body autoradiography
Cmax in mini-pig at 5 mg/kg, po
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
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