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Cyclooxygenase Assay from Article 10.1111/cbdd.12457: "Synthesis, Molecular Modeling, and Biological Evaluation of Novel 1, 3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents."
Assay data:16 Active, 4 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In vitro Cyclooxygenase Inhibition Assay from Article 10.1111/cbdd.12435: "1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and -amyloid aggregation inhibitors: biological evaluation and in silico study."
Assay data:4 Active, 2 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
COX Inhibition Assay from Article 10.3109/14756366.2010.550890: "Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity."
Assay data:5 Active, 2 Activity ≤ 1 µM, 8 Tested
In Vitro Cyclo-Oxygenase Inhibition Assay from Article 10.3109/14756360903179435: "3-arylidene-5-(4-isobutylphenyl)-2(3H)-furanones: a new series of anti-inflammatory and analgesic compounds having antimicrobial activity."
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
COX Inhibitor Screening Assay from Article 10.1016/j.bioorg.2017.04.012: "Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors."
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Cyclooxygenase Inhibition Assay from Article 10.1016/j.bioorg.2017.04.002: "New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents."
Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested
In Vitro COX-1 and COX-2 Inhibitory Assay from Article 10.1016/j.bioorg.2017.03.012: "New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study."
Assay data:15 Active, 1 Activity ≤ 1 µM, 15 Tested
In Vitro Cyclooxygenase (COX) Inhibition Assay from Article 10.1016/j.bioorg.2016.12.008: "Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile."
Assay data:24 Active, 2 Activity ≤ 1 µM, 25 Tested
COX Inhibition Assay from Article 10.1016/j.bioorg.2016.11.014: "In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings."
Assay data:2 Active, 1 Activity ≤ 1 µM, 19 Tested
COX-1/COX-2 Inhibition Colorimetric Assay from Article 10.1016/j.bioorg.2016.11.008: "Design, synthesis, cyclooxygenase inhibition and biological evaluation of new 1,3,5-triaryl-4,5-dihydro-1H-pyrazole derivatives possessing amino/methanesulfonyl pharmacophore."
Assay data:12 Active, 9 Activity ≤ 1 µM, 12 Tested
COX Enzyme Inhibition Assay (Table 2) from Article 10.1021/acschembio.6b00560: "Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
COX Enzyme Inhibition Assay (Table 1) from Article 10.1021/acschembio.6b00560: "Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors."
Assay data:13 Active, 12 Activity ≤ 1 µM, 18 Tested
In vitro COX Inhibition Assay from Article 10.1016/j.bioorg.2016.09.005: "Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities."
Assay data:6 Active, 4 Activity ≤ 1 µM, 7 Tested
Enzyme Kinetics Assay from Article 10.1016/j.bioorg.2016.10.003: "Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach."
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
In vitro COX Inhibition Assay from Article 10.1016/j.bioorg.2016.10.003: "Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach."
Assay data:8 Active, 5 Activity ≤ 1 µM, 8 Tested
In vitro Cyclooxygenase Inhibition Assay from Article 10.1016/j.bioorg.2015.11.001: "Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile."
Assay data:9 Active, 9 Tested
In vitro Cyclooxygenase (COX) Inhibition Assay from Article 10.1016/j.bioorg.2015.09.002: "1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents."
Assay data:26 Active, 3 Activity ≤ 1 µM, 27 Tested
COX1 and COX2 Inhibition Assay from Article 10.1111/cbdd.12469: "Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase."
Assay data:1 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In vitro COX-1 and COX-2 inhibition assay from Article 10.1111/cbdd.12336: "Synthesis, molecular docking, and biological evaluation of some novel hydrazones and pyrazole derivatives as anti-inflammatory agents."
Assay data:12 Active, 1 Activity ≤ 1 µM, 13 Tested
Cyclooxygenase (COX) Inhibition Assay from Article 10.1111/cbdd.12324: "Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study."
Assay data:4 Active, 3 Activity ≤ 1 µM, 9 Tested
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