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Antagonist activity at mouse alpha4beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced current response measured up to 90 secs by FMP assay
Assay data:16 Active, 3 Activity ≤ 1 µM, 41 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Antagonist activity at mouse alpha4beta2 nAChR transfected in HEK293 cells by FLIPR membrane potential blue (FMP) assay
Assay data:1 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity at mouse alpha4/beta2 nAChR expressed in HEK293 cells assessed as inhibition of (S)-nicotine-induced activity by FLIPR membrane potential blue assay
Assay data:7 Active, 1 Activity ≤ 1 µM, 21 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Displacement of [125I]-epibatidine from alpha4beta2 nAChR in mouse cortical membranes
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of [125I]-epibatidine from alpha3beta4 nAChR in mouse cortical membranes
Activity at alpha3beta4* nAChR in mouse interpeduncular nucleus assessed as [3H]ACh release by scintillation counting
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activity at alpha4beta2*nAChR in mouse striatal synaptosomes assessed as alpha-conotoxic MII-resistant DA release relative to control
Activity at alpha4beta2*nAChR in mouse striatal synaptosomes assessed as alpha-conotoxic MII-resistant DA release
Assay data:8 Active, 2 Activity ≤ 1 µM, 10 Tested
Displacement of [125I]epibatidine from alpha4beta2* nAChR in C57BL/6J mouse cortical membrane by gamma counting
Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 12 Tested
Activity at alpha3beta4* nAChR in mouse interpeduncular nucleus assessed as [3H]ACh release by scintillation counting relative to control
Assay data:5 Active, 1 Activity ≤ 1 µM, 12 Tested
Binding affinity against Nicotinic acetylcholine receptor using [3H](-)-nicotine radioligand
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Binding affinity at NAChRs was determined by measuring the displacement of ([3H]Nic) from a preparation of rat cortical membranes.
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Compound was tested for the binding affinity towards nicotinic acetylcholine receptor
Assay data:2 Tested
Compound was tested for the binding affinity towards Nicotinic acetylcholine receptor
Assay data:4 Tested
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